- 询价
- ATCC
- 美国/中国
- xy-264R
- 2025年07月15日
13 年钻石会员
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
4℃保存
- 保质期：
6个月
- 英文名：
Ubiquitin Ubi-1 Monclonal Antibody
- 库存：
1
- 供应商：
上海信裕
- Ubiquitin Ubi-1 Monclonal Antibody保存于运输说明：
- Store at -20°C.
- 详细信息：
-
Description 
Monoclonal Antibody against Ubiquitin Clone Ubi-1 Form Ascites (contains 10mM Sodium Azide) Host Mouse Species Reactivity Human, Bovine, Chicken, Drosophila and C. elegans IsoType IgG1, k light chain Specificity Ubiquitin Ubi-1 Monclonal Antibody Ubiquitin is a highly conserved globular 76 amino acid protein and has a important role in the targeting of proteins for proteolytic degradation. Proteins to be degraded are covalantly coupled to the C-terminus of ubiquitin by means of ubiquitin ligases. The ubiquitin itself is frequently also ubiquitinated, producing a polyubiquitin chain. The polyubquitinated complex is then recognized by a complex of degradative enzymes which together form the proteosome. Interestingly, ubiquitin also becomes covalently bonded to many types of pathological inclusions seen in serious human disease states which appear to be resistant to normal degradation, so that ubiquitin antibodies are very useful for studies of these inclusions. For example the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimers disease, the Lewy bodies seen in Parkinsons disease, and Pick bodies found in Picks disease are all heavily ubiquitinated and can all be readily visualized with ubiquitin antibodies of appropriate specificity.
Antibody Ubi-1 was raised against purified KLH-conjugated ubiquitin. The clone was initially screened on ELISA of the immunogen, and subsequently tested on sections of Alzheimer brain. Clone Ubi-1 was one of several clones which stained neurofibrillary tangles in frozen sectioned material strongly and specifically. Subsequent studies indicated that Ubi-1 is relatively insensitive to formalin fixation and so can be used on mildly fixed histological sections of human brain for studies of Alzheimers disease. The antibody also works on paraffin embedded material. Ubi-1 also recognizes other ubiquitinated inclusion bodies such as the Lewy bodies of Parkinsons disease and the Pick bodies in Picks disease in formalin fixed tissues.Uses This antibody is effective in immunoblotting, immunohistochemistry and ELISA. Ubi-1 is excellent for detection of ubiquinated inclusions seen in human neurodegenerative diseases such as the neurofibrillary tangles of Alzheimers disease. Suggested Working Dilution Ubiquitin Ubi-1 Monclonal Antibody The optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval. - Western blot: 1:1,000*
- Immunofluorescence: 1:500
Notes * Predicted MW = 8.5kD Storage Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C. References Boutajangout A, Authelet M, Blanchard V, Touchet N, Tremp G, Pradier L, Brion JP. Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimers disease mutants of APP and presenilin-1.Neurobiol Dis. 15:47-60, 2004.
Wang DS, Bennett DA, Mufson EJ, Mattila P, Cochran E, Dickson DW. Contribution of changes in ubiquitin and myelin basic protein to age-related cognitive decline.Neurosci. Res. 48:93-100, 2004.
He CZ, Hays AP. Expression of peripherin in ubiquinated inclusions of amyotrophic lateral sclerosis. J. Neurol. Sci. 217:47-54, 2004.
Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O. Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol. Cell Biol. 22:3316-3326, 2002.
Wirbelauer C, Sutterluty H, Blondel M, Gstaiger M, Peter M, Reymond F, Krek W. The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts. EMBO J. 19:5362-5375, 2000.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Ubiquitin Ubi-1 Monclonal Antibody
- xy-6277R CYP2W1细胞色素P450 2W1抗体
xy-6278R Choline dehydrogenase胆碱脱氢酶抗体
xy-5764R CIAPIN1细胞因子诱导凋亡抑制因子1
xy-6609R Cyclophilin B亲环蛋白PPIB抗体
xy-6226R CT13肿瘤/睾丸抗原13抗体
xy-4267R CDKN2AIP钙反应因子抗体
xy-5746R CDC2L1细胞分裂周期蛋白2亚型1抗体
xy-15116R C20orf74 20号染色体开放阅读框74抗体
xy-6620R CRHR2促肾上腺皮质释放激素受体2抗体
xy-9694R C20orf13220号染色体开放阅读框132抗体
xy-4595R Collagen IVIV型胶原蛋白/4型胶原蛋白/胶原蛋白4抗体
xy-4247R CHRNB2型乙酰胆碱受体B2抗体
xy-15114R C20orf70 20号染色体开放阅读框70抗体
xy-5911R Cyclophilin B亲环蛋白（亲环素）PPIB抗体
xy-15287R C8ORF348号染色体开放阅读框34抗体
xy-6678R M CadherinM钙粘附分子抗体
xy-6655R Cryopyrin细胞凋亡诱导蛋白NALP3抗体
xy-6656R Cyclin B2周期素B2抗体
xy-6658R Calumenin钙腔蛋白
xy-15241R C6orf2226号染色体开放阅读框222抗体
xy-5833R Cornulin热休克蛋白58抗体
xy-6695R Cytochrome P450 17A1细胞色素C P450 17A1抗体
xy-6683R CLDND1膜蛋白CLDND1抗体
xy-6652R CRMP1二氢嘧啶酶相关蛋白1抗体
xym-4541M Chloramphenicol氯霉素单克隆抗体
xy-6659R CD98CD98重链抗原抗体
xy-6701R Calpastatin钙蛋白酶抑制蛋白抗体
xy-6705R cGKIcGMP依赖性蛋白激酶1抗体
xy-6709R CaIPLA2胞浆钙独立磷脂酶A2抗体
xy-15082R C1orf98 1号染色体开放阅读框98抗体
xy-8310R COX4NBCOX4NB蛋白抗体
xy-8331R CPXCR1肿瘤/睾丸抗原77抗体
xy-6934R CD81CD81抗体
xy-11656R COQ10B辅酶Q10B抗体
xy-8663R CRLF1细胞因子受体样因子1抗体
xy-11822R CSAD半胱氨酸亚磺酸脱羧酶抗体
xy-6407R CHCHD2丙型肝炎NS2反式调节蛋白/衰老相关的基因10蛋白抗体
xy-6436R CYP11B2醛固酮合成酶CYP11B2抗体
xy-7834R CDCA8细胞分裂周期蛋白8抗体
xy-6908R CCDC5卷曲螺旋结构域蛋白5抗体
xy-7832R CDC16细胞分裂周期蛋白16抗体
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
Ubiquitin Ubi-1 Monclonal Antibody
询价
