Stemolecule™ Pifithrin-μ

Stemolecule™ Pifithrin-μ详细信息：
Product Overview

Stemolecule™ Pifithrin-µ inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. The mechanism of action of PFT-µ is different from PFT-α since PFT-µ inhibits the p53 mitochondrial pathway but does not affect any additional transcriptional functions of p53. The reduction of p53 activity has been shown to enhance reprogramming efficiency of human and mouse somatic cells. PFT-µ rescues cells from lethal γ-irradiation induced cell death and protects mice from doses of radiation that cause lethal hematopoietic syndrome.



Stemolecule™ Pifithrin-μProduct Specifications

Size / Quantity 5 mg
Alternate Name PFT-µ, 2-Phenylethynesulfonamide
CAS Number 64984-31-2
Chemical Formula C8H7NO2S
Structure [structure graphics]
Formulation White to off-white solid
Stemolecule™ Pifithrin-μMolecular Weight 181.21
Purity ≥97%
Solubility Soluble in DMSO (55 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 2759 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
Storage Store at 4oC. Protect from light. Following reconstitution, store aliquots at -20C.
Quality Control The purity of Pifithrin-µ was determined by HPLC analysis. The accurate mass of Pifithrin-µ was determined by mass spectrometry. Cellular toxicity of Pifithrin-µ was tested on mouse embryonic stem cells.
Notice to Purchaser Purchaser represents and warrants that it will use Stemolecule™ Pifithrin-μ purely for research purposes, not for diagnostic use, not for resale, and not for use in humans or veterinary applications. Stemgent will not be held responsible for patent infringement or other violations that may occur with the use of our products.
Stemolecule™ Pifithrin-μ
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