Stemolecule™ Pifithrin-α

Stemolecule™ Pifithrin-α详细信息：
Product Overview

Stemolecule™ Pifithrin-α (PFT-α) is a reversible inhibitor of p53 dependent apoptosis and transcriptional activation for cyclin G, p21/waf1, and mdm2 expression. The reduction of p53 activity has been shown to enhance reprogramming efficiency of human and mouse somatic cells. PFT-α enhances cell survival after treatment with UV irradiation or cytotoxic compounds. PFT-α protects wild-type mice against lethal doses of radiation without inducing visible tumors. The possibility exists that PFT-α may be used to reduce the side effects of radiation or chemotherapy for cancers that have lost p53 functions without affecting sensitivity of the tumors to treatment.

Stemolecule™ Pifithrin-αProduct Specifications

Size / Quantity 5 mg
Alternate Name PFT-α, 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolyethanone hydrobromide, 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)benzothiazoyl)ethanone HBr
CAS Number 63208-82-2
Chemical Formula C16H18N2OS-HBr
Structure [structure graphics]
Formulation Off-white solid
Molecular Weight 367.30
Stemolecule™ Pifithrin-αPurity ≥95%
Solubility Soluble in DMSO (54 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 1361 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
Storage Store at 4oC. Protect from light. Following reconstitution, store aliquots at -20C.
Stability Stock solutions stable at -20°C for 6 months.
Quality Control The purity of Pifithrin-α was determined by HPLC analysis. The accurate mass of Pifithrin-α was determined by mass spectrometry. Cellular toxicity of Pifithrin-α was tested on mouse embryonic stem cells.
Notice to Purchaser Purchaser represents and warrants that it will use Stemolecule™ Pifithrin-α purely for research purposes, not for diagnostic use, not for resale, and not for use in humans or veterinary applications. Stemgent will not be held responsible for patent infringement or other violations that may occur with the use of our products
Stemolecule™ Pifithrin-α
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