Chemical Name: N-(3-(3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl) phenyl) acetamide
Appearance: White to off-white solid
Solubility: Soluble in DMSO (20 mg/ml with slightly warming)
Storage:Store solid at -20 ºC for the stability of three years
储存液配制
储存液(1 ml DMSO)
1 mM
5 mM
10 mM
25 mM
质量(mg)
0.6154
3.0770
6.1539
15.3848
Trametinib结构式
参考文献
[1] Gilmartin AG, et al. GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition. Clin. Cancer Res. 17(5), 989-1000 (2011).
[2] Yamaguchi T, et al. Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo. Int J Oncol. 39(1):23-31 (2011).
[3] Greger JG, et al. Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations. Mol Cancer Ther. 11(4):909-20 (2012).