Clorgyline hydrochloride

Clorgyline hydrochloride产品描述

Clorgyline hydrochloride是Clorgyline的盐酸盐形式。Clorgyline是一种有效的，时间和浓度依赖的MAO-A抑制剂，IC₅₀ 为2.76 μM ^[1]。大鼠肝脏线粒体中Clorgyline和MAO-A之间可逆相互作用的K_i值比MAO-B低1000倍 ^[2]。Clorgyline也能降低血浆DHPG和DHMA的生成及OMDA代谢，并增加血浆去甲变肾上腺素 ^[3]。C-11标记的Clorgyline可用于正电子发射计算机断层扫描测量人脑MAO-A ^[4]。

靶点

靶点	MAO-A
IC50（半数有效浓度）	2.76 μM [1]

Clorgyline hydrochloride化学特性

Cas No.: 17780-75-5	分子量: 308.63
分子式: C13H15Cl2NO HCl	纯度: ≥98%
同义名: Clorgyline HCl
化学名: 3-(2,4-dichlorophenoxy)-N-methyl-N-prop-2-ynylpropan-1-amine;hydrochloride
外观: 白色至灰白色固体
溶解: 溶于水 (up to 100 mM)
保存：：3年 -20℃粉状

储存液配制

储存液 (1 ml water体系)	1 mM	5 mM	10 mM	25 mM	50 mM	100 mM
质量(mg)	0.3086	1.5432	3.0863	7.7158	15.4316	30.8631

Clorgyline hydrochloride结构式

参考文献

[1] Tong X, Chen R, Zhang TT, Han Y, Tang WJ, Liu XH. Design and synthesis of novel 2-pyrazoline-1-ethanone derivatives as selective MAO inhibitors. Bioorg Med Chem. 13. pii: S0968-0896(14)00848-7(2014).
[2] Fowler C. J., et al. The nature of the inhibition of rat liver monoamine oxidase types A and B by the acetylenic inhibitors clorgyline, l-deprenyl and pargyline. Biochem. Pharmacol. 31, 3555–3561(1982).
[3] Figueiredo IV, et al. The role of MAO-A and MAO-B in the metabolic degradation of noradrenaline in human arteries. J Auton Pharmacol. 18(2):123-8(1998).
[4] J. S. Fowler, et al. Non-MAO A binding of clorgyline in white matter in human brain. Journal of Neurochemistry.79(5) :1039-46(2001).

Clorgyline hydrochloride

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