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- 保存条件：
-20°C
- 保质期：
1年
- 英文名：
Thrombin
- 库存：
100⁺支
- 供应商：
上海睿安生物13611631389
- 规格：
10KU/支
Sigma货号T4648凝血酶(Thrombin)上海睿安生物13611631389
凝血酶(来源于牛血浆)
lyophilized powder,40-500 NIH units/mg protein(biuret)
别名:IIa 因子
说明
一般描述:凝血酶是止血相关的最终凝血蛋白酶，对促凝血和抗凝血作用都有所促进。
应用:凝血酶可用于含有可接近的凝血酶识别位点以除去亲和标签的重组融合蛋白的位点特异性切割。凝血酶已用于一项对从脓毒性休克患者中持续性低凝状态进行评估的研究中。
生化/生理作用:丝氨酸蛋白酶，选择性断开纤维蛋白原中的精氨酸-甘氨酸键，形成纤维蛋白以及纤维蛋白肽A和B。
单位定义:活性以NIH单位表示，通过与NIH凝血酶参考标准品直接对比确定。
外形:含有氯化钠和Tris-HCl，pH 7.0的冻干粉
制备说明:用牛脑促凝血酶原激酶进行激活。
分析说明:基于Biggs改性法的NIH分析过程使用0.2ml稀释血浆(由血浆与等量生理盐水混合制得)作为底物，以及0.1ml凝血酶样品(在含1%白蛋白缓冲液中保持稳定)。只使用15-25秒之间的凝血时间分析凝血酶浓度。
活性是通过与一种K批次的NIH凝血酶参考标准品进行直接比较而得到并以NIH单位进行表达的。
同行评审论文(部分文献)
Persistent hypocoagulability in patients with septic shock predicts greater hospital mortality: impact of impaired thrombin generation
Massion, P., et al.
Intensive Care Medicine, 1823(8), 1316-1323 (2012)
Bioprinted Skin Recapitulates Normal Collagen Remodeling in Full-Thickness Wounds.
Adam M Jorgensen et al.
Tissue engineering. Part A, 26(9-10), 512-526 (2019-12-22)
Over 1 million burn injuries are treated annually in the United States, and current tissue engineered skin fails to meet the need for full-thickness replacement. Bioprinting technology has allowed fabrication of full-thickness skin and has demonstrated the ability to close
5'-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR.
Marek R Baranowski et al.
Nucleic acids research, 48(15), 8209-8224 (2020-06-10)
The high sensitivity of 19F nucleus to changes in the chemical environment has promoted the use of fluorine-labeled molecular probes to study structure and interactions of nucleic acids by 19F NMR. So far, most efforts have focused on incorporating the
ULK1 phosphorylates Exo70 to suppress breast cancer metastasis.
Liyuan Mao et al.
Nature communications, 11(1), 117-117 (2020-01-09)
Increased expression of protein kinase ULK1 was reported to negatively correlate with breast cancer metastasis. Here we report that ULK1 suppresses the migration and invasion of human breast cancer cells. The suppressive effect is mediated through direct phosphorylation of Exo70
Ultrasound-guided platelet-rich plasma injection and multimodality ultrasound examination of peripheral nerve crush injury.
Yaqiong Zhu et al.
NPJ Regenerative medicine, 5(1), 21-21 (2020-12-11)
Ultrasound-guided platelet-rich plasma (PRP) injection is able to make up for the limitations of applying a single growth factor. The goal of this study was to investigate the effects of serial ultrasound-guided PRP injections of the appropriate concentration on the
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文献和实验该产品被引用文献
Sigma货号T4648凝血酶(Thrombin)上海睿安生物13611631389
凝血酶(来源于牛血浆)
lyophilized powder,40-500 NIH units/mg protein(biuret)
别名:IIa 因子
说明
一般描述:凝血酶是止血相关的最终凝血蛋白酶，对促凝血和抗凝血作用都有所促进。
应用:凝血酶可用于含有可接近的凝血酶识别位点以除去亲和标签的重组融合蛋白的位点特异性切割。凝血酶已用于一项对从脓毒性休克患者中持续性低凝状态进行评估的研究中。
生化/生理作用:丝氨酸蛋白酶，选择性断开纤维蛋白原中的精氨酸-甘氨酸键，形成纤维蛋白以及纤维蛋白肽A和B。
单位定义:活性以NIH单位表示，通过与NIH凝血酶参考标准品直接对比确定。
外形:含有氯化钠和Tris-HCl，pH 7.0的冻干粉
制备说明:用牛脑促凝血酶原激酶进行激活。
分析说明:基于Biggs改性法的NIH分析过程使用0.2ml稀释血浆(由血浆与等量生理盐水混合制得)作为底物，以及0.1ml凝血酶样品(在含1%白蛋白缓冲液中保持稳定)。只使用15-25秒之间的凝血时间分析凝血酶浓度。
活性是通过与一种K批次的NIH凝血酶参考标准品进行直接比较而得到并以NIH单位进行表达的。
同行评审论文(部分文献)
Persistent hypocoagulability in patients with septic shock predicts greater hospital mortality: impact of impaired thrombin generation
Massion, P., et al.
Intensive Care Medicine, 1823(8), 1316-1323 (2012)
Bioprinted Skin Recapitulates Normal Collagen Remodeling in Full-Thickness Wounds.
Adam M Jorgensen et al.
Tissue engineering. Part A, 26(9-10), 512-526 (2019-12-22)
Over 1 million burn injuries are treated annually in the United States, and current tissue engineered skin fails to meet the need for full-thickness replacement. Bioprinting technology has allowed fabrication of full-thickness skin and has demonstrated the ability to close
5'-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR.
Marek R Baranowski et al.
Nucleic acids research, 48(15), 8209-8224 (2020-06-10)
The high sensitivity of 19F nucleus to changes in the chemical environment has promoted the use of fluorine-labeled molecular probes to study structure and interactions of nucleic acids by 19F NMR. So far, most efforts have focused on incorporating the
ULK1 phosphorylates Exo70 to suppress breast cancer metastasis.
Liyuan Mao et al.
Nature communications, 11(1), 117-117 (2020-01-09)
Increased expression of protein kinase ULK1 was reported to negatively correlate with breast cancer metastasis. Here we report that ULK1 suppresses the migration and invasion of human breast cancer cells. The suppressive effect is mediated through direct phosphorylation of Exo70
Ultrasound-guided platelet-rich plasma injection and multimodality ultrasound examination of peripheral nerve crush injury.
Yaqiong Zhu et al.
NPJ Regenerative medicine, 5(1), 21-21 (2020-12-11)
Ultrasound-guided platelet-rich plasma (PRP) injection is able to make up for the limitations of applying a single growth factor. The goal of this study was to investigate the effects of serial ultrasound-guided PRP injections of the appropriate concentration on the
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Sigma货号T4648凝血酶(Thrombin)上海睿安生物13611631389
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