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- H9395-1mg
- 2025年10月27日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件：
2-8°C
- 保质期：
1年
- 英文名：
α-Hemolysin(α-Toxin)
- 库存：
100⁺瓶
- 供应商：
上海睿安生物13611631389
- 规格：
1mg/瓶
Sigma货号H9395-1mg供应(α-溶血素)现货α-Hemolysin上海睿安生物13611631389
一般描述
α-Hemolysin, a pore-forming cytotoxin is an extracellular protein secreted by most strains of pathogenic Staphy_lococcus aureus. It is secreted as a water-soluble monomer and is a small β-barrel protein.
应用
α-Hemolysin was used in a study to test the efflux pump and haemolysin activity of Escherichia coli of dairy origin. It was also used to test its adaptation to benzalkonium chloride and the effect of ciprofloxacin on biofilm formation.
α-Hemolysin from Staphy_lococcus aureus has been used:
- as a component of electrolyte solution for testing pore formation in lipid bilayer using electrophysiological measurements
- to test its osteogenesis suppressive effects in bone marrow stromal cells (BMSCs)
- in the preparation of α-hemolysin molecular imprinted polymer (MIP) for Biacore and surface plasmon resonance
生化/生理作用
α-Hemolysin is selectively hemolytic and the monomeric form binds to a membrane and specific receptors are not required for binding. Upon binding to biological membranes and/or artificial membranes, self-oligomerization occurs, resulting in ring structures (hexameric aggregates) believed to represent transmembrane pores, which are permeable to ions and small metabolites. It has a marked preference for rabbit red blood cells. α-hemolysin stimulates cellular phospholipases and induces a Ca2+ influx. It leads to membrane disruption of the endothelial barrier and leakage of cytoplasmic components and osmotic lysis of the cells. α-hemolysin is implicated in the pathogenesis of sepsis.
包装:Package size based on protein content
单位定义
One hemolytic unit will cause 50% lysis of a 1% suspension of rabbit red blood cells in phosphate buffered saline, pH 7.0, containing 1% bovine serum albumin after 30 min at 37 °C followed by refrigeration for 30 min at 4 °C.
说明
一般描述:α-溶血素是一种成孔细胞毒素，它是大多数致病性金黄色葡萄_球菌菌株分泌的一种细胞外蛋白。它是以水溶性单体的形式分泌，是一种小型β桶状蛋白。
应用
- 作为电解质溶液的一种成分，用于通过电生理测量测试脂双层中的孔形成
- 测试其在骨髓基质细胞(BMSCs)中的成骨抑制作用
- 制备用于 Biacore 和表面等离子体共振的α溶血素分子印迹聚合物(MIP)
生化/生理作用
包装:包装尺寸基于蛋白质含量
单位定义:一个溶血单元是在37°C下30分钟，然后在4°C下冷藏30分钟后，悬浮在pH 7.0磷酸盐缓冲盐水中含1%牛血清白蛋白的1%兔红细胞有50%溶解。
同行评审论文
Staphy_lococcus aureus alpha-toxin activates phospholipases and induces a Ca2+ influx in PC12 cells.
D Fink et al.
Cellular signalling, 1(4), 387-393 (1989-01-01)
Staphylococcal alpha-toxin at subcytotoxic concentrations stimulated phosphatidylinositol turnover and arachidonic acid release in undifferentiated cultures of pheochromocytoma PC12 cells. Stimulation of phospholipase A2 but not C was dependent on extracellular calcium. Addition of staphylococcal alpha-toxin to PC12 cells caused a
Generation of chip based microelectrochemical cell arrays for long-term and high-resolution recording of ionic currents through ion channel proteins
Zheng T, et al.
Sensors and Actuators B, Chemical, 205 (205)
Stable polymer bilayers for protein channel recordings at high guanidinium chloride concentrations.
Luning Yu et al.
Biophysical journal, 120(9), 1537-1541 (2021-02-23)
The use of chaotropic reagents is common in biophysical characterization of biomolecules. When the study involves transmembrane protein channels, the stability of the protein channel and supporting bilayer membrane must be considered. In this letter, we show that planar bilayers
Myricetin protects Galleria mellonella against Staphy_lococcus aureus infection and inhibits multiple virulence factors.
L N Silva et al.
Scientific reports, 7(1), 2823-2823 (2017-06-08)
Staphy_lococcus aureus is an opportunistic pathogen related to a variety of life-threatening infections but for which antimicrobial resistance is liming the treatment options. We report here that myricetin, but not its glycosylated form, can remarkably decrease the production of several
Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer.
Rakez Kayed et al.
The Journal of biological chemistry, 284(7), 4230-4237 (2008-12-23)
Amyloid oligomers are believed to play causal roles in several types of amyloid-related neurodegenerative diseases. Several different types of amyloid oligomers have been reported that differ in morphology, size, or toxicity, raising the question of the pathological significance and structural
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文献和实验Sigma货号H9395-1mg供应(α-溶血素)现货α-Hemolysin上海睿安生物13611631389
一般描述
α-Hemolysin, a pore-forming cytotoxin is an extracellular protein secreted by most strains of pathogenic Staphy_lococcus aureus. It is secreted as a water-soluble monomer and is a small β-barrel protein.
应用
α-Hemolysin was used in a study to test the efflux pump and haemolysin activity of Escherichia coli of dairy origin. It was also used to test its adaptation to benzalkonium chloride and the effect of ciprofloxacin on biofilm formation.
α-Hemolysin from Staphy_lococcus aureus has been used:
- as a component of electrolyte solution for testing pore formation in lipid bilayer using electrophysiological measurements
- to test its osteogenesis suppressive effects in bone marrow stromal cells (BMSCs)
- in the preparation of α-hemolysin molecular imprinted polymer (MIP) for Biacore and surface plasmon resonance
生化/生理作用
α-Hemolysin is selectively hemolytic and the monomeric form binds to a membrane and specific receptors are not required for binding. Upon binding to biological membranes and/or artificial membranes, self-oligomerization occurs, resulting in ring structures (hexameric aggregates) believed to represent transmembrane pores, which are permeable to ions and small metabolites. It has a marked preference for rabbit red blood cells. α-hemolysin stimulates cellular phospholipases and induces a Ca2+ influx. It leads to membrane disruption of the endothelial barrier and leakage of cytoplasmic components and osmotic lysis of the cells. α-hemolysin is implicated in the pathogenesis of sepsis.
包装:Package size based on protein content
单位定义
One hemolytic unit will cause 50% lysis of a 1% suspension of rabbit red blood cells in phosphate buffered saline, pH 7.0, containing 1% bovine serum albumin after 30 min at 37 °C followed by refrigeration for 30 min at 4 °C.
说明
一般描述:α-溶血素是一种成孔细胞毒素，它是大多数致病性金黄色葡萄_球菌菌株分泌的一种细胞外蛋白。它是以水溶性单体的形式分泌，是一种小型β桶状蛋白。
应用
- 作为电解质溶液的一种成分，用于通过电生理测量测试脂双层中的孔形成
- 测试其在骨髓基质细胞(BMSCs)中的成骨抑制作用
- 制备用于 Biacore 和表面等离子体共振的α溶血素分子印迹聚合物(MIP)
生化/生理作用
包装:包装尺寸基于蛋白质含量
单位定义:一个溶血单元是在37°C下30分钟，然后在4°C下冷藏30分钟后，悬浮在pH 7.0磷酸盐缓冲盐水中含1%牛血清白蛋白的1%兔红细胞有50%溶解。
同行评审论文
Staphy_lococcus aureus alpha-toxin activates phospholipases and induces a Ca2+ influx in PC12 cells.
D Fink et al.
Cellular signalling, 1(4), 387-393 (1989-01-01)
Staphylococcal alpha-toxin at subcytotoxic concentrations stimulated phosphatidylinositol turnover and arachidonic acid release in undifferentiated cultures of pheochromocytoma PC12 cells. Stimulation of phospholipase A2 but not C was dependent on extracellular calcium. Addition of staphylococcal alpha-toxin to PC12 cells caused a
Generation of chip based microelectrochemical cell arrays for long-term and high-resolution recording of ionic currents through ion channel proteins
Zheng T, et al.
Sensors and Actuators B, Chemical, 205 (205)
Stable polymer bilayers for protein channel recordings at high guanidinium chloride concentrations.
Luning Yu et al.
Biophysical journal, 120(9), 1537-1541 (2021-02-23)
The use of chaotropic reagents is common in biophysical characterization of biomolecules. When the study involves transmembrane protein channels, the stability of the protein channel and supporting bilayer membrane must be considered. In this letter, we show that planar bilayers
Myricetin protects Galleria mellonella against Staphy_lococcus aureus infection and inhibits multiple virulence factors.
L N Silva et al.
Scientific reports, 7(1), 2823-2823 (2017-06-08)
Staphy_lococcus aureus is an opportunistic pathogen related to a variety of life-threatening infections but for which antimicrobial resistance is liming the treatment options. We report here that myricetin, but not its glycosylated form, can remarkably decrease the production of several
Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer.
Rakez Kayed et al.
The Journal of biological chemistry, 284(7), 4230-4237 (2008-12-23)
Amyloid oligomers are believed to play causal roles in several types of amyloid-related neurodegenerative diseases. Several different types of amyloid oligomers have been reported that differ in morphology, size, or toxicity, raising the question of the pathological significance and structural
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