PDGFRb / CD140b抗体

PDGFRb / CD140b抗体产品信息

免疫原 :
Recombinant human PDGFRb protein ( Catalog#10514-H08H )
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human PDGFRb extracellular domain ( rh PDGFRb ; Catalog#10514-H08H ; NP_002600.1 ; Met 1- Lys 531 ). PDGFRb specific IgG was purified by human PDGFRb affinity chromatography.
PDGFRb / CD140b抗体背景综述
Beta-type platelet-derived growth factor receptor, also known as CD140b, PDGFRB, PDGF-R-beta, PDGF receptor-β, is a member of the protein kinase superfamily and CSF-1/PDGF receptor subfamily. The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms. The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-α and -β. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -αα, -ββ and -αβ. The extracellular region of the PDGF receptor-β consists of five immunoglobulin-like domains while the intracellular part is a tyrosine kinase domain. The ligand-binding sites of PDGF receptor-α and -β are located to the three first immunoglobulin-like domains. PDGF-CC specifically interacts with PDGFR-αα and -αβ, but not with –ββ, and thereby resembles PDGF-AB. PDGF-DD binds to PDGFR-ββ with high affinity, and to PDGFR-αβ to a much lower extent and is regarded as PDGFR-ββ specific. PDGF-AA binds only to PDGFR-αα, while PDGF-BB is the only PDGF that can bind all three receptor combinations with high affinity.
PDGFRb / CD140b抗体相关产品如下：
hz-12311R LRRC23LRRC23蛋白抗体
hz-12312R LRRC39LRRC39蛋白抗体
hz-8878R LC3自噬微管相关蛋白轻链3抗体
hz-12342R L3MBTL3L3MBTL3蛋白抗体
hz-12339R LRRC25富含亮氨酸重复蛋白25抗体
hz-2631R IL-31RA/CRL3白介素31受体a抗体
hz-9387R LRSAM1LRSAM1蛋白抗体
hz-7336R Limd1LIM结构域蛋白1抗体
hz-2338R Lactic acid bacterial protein surface乳酸菌菌体表面蛋白抗体
hz-4629R Layilin透明质酸受体抗体
hz-3908R LTA4H白三烯A4水解酶抗体
hz-2342R LXR alpha肝脏X受体抗体
hz-6542R LAPTM4B溶酶体蛋白跨膜β4抗体
hz-6545R LRRN5富含亮氨酸重复神经元5抗体
hz-6546R Lipophilin B亲脂性蛋白B抗体
hz-6543R LDOC1癌症亮氨酸拉链下调因子1抗体
hz-6544R LOXL2赖氨酰氧化酶相关蛋白2抗体
hz-5890R Lumican基膜聚糖蛋白抗体
hz-10499R Listeriolysin李斯特菌溶胞素抗体
hz-6249R LCMT1亮氨酸羧基甲基转移酶1抗体
hz-5937R LETMD1宫颈癌原癌基因2抗体
hz-5790R LOXL4赖氨酰氧化酶样蛋白4抗体
hz-5810R Lactoferrin乳铁蛋白抗体
hz-7503R Laminin 1+2层粘连蛋白1+2抗体
hz-6815R LRRC15富含亮氨酸重复蛋白15抗体
hz-11530R LAR受体蛋白酪氨酸磷酸酶F抗体
hz-13777R Phospho-5-Lipoxygenase(Ser524)磷酸化5-脂氧合酶抗体
hz-2787R LMP2低分子质量蛋白2抗体
hz-2775R LIMK1单丝氨酸蛋白激酶1抗体
hz-2796R LMP7低分子量蛋白酶体7抗体
hz-0952R LH促黄体生成素抗体
hz-4973R Laminin alpha 1层粘蛋白α1抗体
hz-15591R LETM1LETM1蛋白抗体
hz-1810R LDHA乳酸脱氢酶抗体
hz-1532R phospho-LKB1 (Thr363)磷酸化丝氨酸/苏氨酸蛋白激酶抗体
hz-1526R Laminin Beta 1层粘连蛋白β1抗体