Trk-C / NTRK3 / TRKC抗体

Trk-C / NTRK3 / TRKC抗体产品信息

免疫原 :
Recombinant human Trk-C protein ( Catalog#10048-H08H )
抗体类型: Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 :
7F7E12G8
抗体宿主 :
Mouse IgG2b
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human Trk-C / NTRK3 ( rh Trk-C ; Catalog#10048-H08H ; NP_001007157.1 ; Met1-Asp428). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Trk-C / NTRK3 / TRKC抗体背景综述
TrkC is a member of the neurotrophic tyrosine receptor kinase (NTRK) family which mediates the biological activities of neurotrophins. The Trk proteins exhibit different ligand specificities, and TrkC is a functional receptor for neurotrophin 3 (NT3), but not for the highly related neurotrophic factors NGF or BDNF. TrkC is a membrane-bound glycoprotein preferentially expressed in the brain, primarily the neural lineages. Upon neurotrophin binding, TrkC phosphorylates itself and down stream molecules of the related pathways, and therefore mediates the NT3-stimulated neurotrophic effects. This protein thus leads to cell proliferation, differentiation and plays a role in the development of proprioceptive neurons. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Multiple isoforms of TrkC is produced including receptors showing impaired signaling responses with inserts in the catalytic domain.
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