SerpinA7 / TBG抗体

SerpinA7 / TBG抗体产品信息

免疫原 :
Recombinant human SerpinA7 protein ( Catalog#10993-H08H )
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human SerpinA7 ( rh SerpinA7 ; Catalog#10993-H08H ; NP_000345.2 ; Met 1 - Ala 415 ). Total IgG was purified by Protein A affinity chromatography.
SerpinA7 / TBG抗体背景综述
Thyroxine-binding globulin, also known as T4-binding globulin, SerpinA7 and TBG, is a secreted protein which belongs to the serpin family. TBG is synthesized primarily in the liver and secreted in plasma. Genomically, TBG is a serpin, although it has no inhibitory function like many other members of this class of proteins. TBG binds thyroid hormone in circulation. It is one of three proteins (along with transthyretin and albumin ) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3’-triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in serum. Due to the very low serum concentration of T4 and T3. TBG is rarely more than 25% saturated with its ligand. Unlike transthyretin and albumin, TBG has a single binding site for T4/T3. TBG tests are sometimes used in finding the reason for elevated or diminished levels of thyroid hormone, and defects in SerpinA7 are a cause of TBG deficiency.
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