Latexin / LXN / TCI抗体

Latexin / LXN / TCI抗体产品信息

免疫原 :
Recombinant human Latexin protein ( Catalog#10211-H07E )
抗体类型: Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, E.coli-derived, recombinant human Latexin ( rh Latexin ; Catalog#10211-H07E ; NP_064554.3 ; Glu 2 - Glu 222 ). Total IgG was purified by Protein A affinity chromatography
Latexin / LXN / TCI抗体背景综述
Human Latexin, also known as Tissue carboxypeptidase inhibitor, Endogenous carboxypeptidase inhibitor (TCI or ECI), is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart, prostate, ovary, kidney, pancreas, and colon, but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets, and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors, Latexin is related to a human putative tumor suppressor protein, TIG1. In addition, Latexin is also implicated in Alzheimer's disease.
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