GM-CSFR / CD116 / CSF2RA抗体

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic cytokine that regulates differentiation, survival, and proliferation of colony-forming unit-granulocyte-macrophage progenitor cells. It performs biological functions by binding with high affinity to a specific receptor complex which is composed of a cytokine-specific alpha-chain (GM-CSF receptor alpha-chain, αGMR) and a beta-chain shared with the receptors for interleukin-3 and interleukin-5. GM-CSFR has been identified to mediate the activation of Janus kinase (Jak)– Stat and MAPK pathways. The alpha subunit binds GM-CSF with low affinity, whereas the beta subunit does not bind GM-CSF by itself. Although the cytoplasmic domain of αGMR is short (54 aa), it is essential for cell differentiation, proliferation, and survival induced by GM-CSF. αGMR also appears to have a role independent of βGMR in that αGMR signals for increased glucose transport through activation of phosphatidylinositol 3-kinase.
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