CD116 / GM-CSFR / CSF2RA抗体

CD116 / GM-CSFR / CSF2RA抗体产品信息免疫原 : Recombinant human CD116 protein ( Catalog#10701-H08H )

抗体类型: Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 4A4B3A2
抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human CD116 / GM-CSFR ( rh CD116 ; Catalog#10701-H08H ; P15509-1 ; Met 1 - Gly 320 ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography
CD116 / GM-CSFR / CSF2RA抗体背景综述
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic cytokine that regulates differentiation, survival, and proliferation of colony-forming unit-granulocyte-macrophage progenitor cells. It performs biological functions by binding with high affinity to a specific receptor complex which is composed of a cytokine-specific alpha-chain (GM-CSF receptor alpha-chain, αGMR) and a beta-chain shared with the receptors for interleukin-3 and interleukin-5. GM-CSFR has been identified to mediate the activation of Janus kinase (Jak)– Stat and MAPK pathways. The alpha subunit binds GM-CSF with low affinity, whereas the beta subunit does not bind GM-CSF by itself. Although the cytoplasmic domain of αGMR is short (54 aa), it is essential for cell differentiation, proliferation, and survival induced by GM-CSF. αGMR also appears to have a role independent of βGMR in that αGMR signals for increased glucose transport through activation of phosphatidylinositol 3-kinase.
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