Enoyl-ACP Reductase / FABI抗体

Enoyl-ACP Reductase / FABI抗体产品信息免疫原 : Recombinant E.coli Enoyl-ACP Reductase / FABI protein (Catalog#30001-E07E)

Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 : Rabbit IgG

缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : Produced in rabbits immunized with purified, recombinant E.coli Enoyl-ACP Reductase / FABI (rE.coli Enoyl-ACP Reductase / FABI; Catalog#30001-E07E; NP_287908.1; Gly 2-Lys 262). Enoyl-ACP Reductase / FABI specific IgG was purified by E.coli Enoyl-ACP Reductase / FABI affinity chromatography.
Enoyl-ACP Reductase / FABI抗体 Background
Enoyl-ACP reductase, also known as NADH-dependent enoyl-ACP reductase and FABI, is a cell inner membrane and peripheral membrane protein which belongs to theshort-chain dehydrogenases/reductases (SDR) family and FabI subfamily. Microorganisms produce many kinds of antibiotics which function in an antagonistic capacity in nature where they have much competition. Bacterial FAS provides essential fatty acids for use in the assembly of key cellular components. Among them, FABI is an enoyl-ACP reductase which catalyzes the final and rate-limiting step of bacterial FAS. The antibiotic diazaborine interferes with the activity by binding to the protein. FABI is a potential target for selective antibacterial action, because it shows low overall sequence homology with mammalian enzymes. Various compounds have been reported as inhibitors of bacterial FabI-inhibitory compounds.
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