GM-CSFR / CD116 / CSF2RA抗体

GM-CSFR / CD116 / CSF2RA抗体产品信息

免疫原 :
Recombinant human CD116 protein ( Catalog#10701-H08H )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, human cell-derived, recombinant human CD116 / GM-CSFR ( rh GM-CSFR ; Catalog#10701-H08H ; P15509-1 ; Met 1-Gly 320 ). CD116 specific IgG was purified by human CD116 affinity chromatography.
GM-CSFR / CD116 / CSF2RA抗体背景综述
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic cytokine that regulates differentiation, survival, and proliferation of colony-forming unit-granulocyte-macrophage progenitor cells. It performs biological functions by binding with high affinity to a specific receptor complex which is composed of a cytokine-specific alpha-chain (GM-CSF receptor alpha-chain, αGMR) and a beta-chain shared with the receptors for interleukin-3 and interleukin-5. GM-CSFR has been identified to mediate the activation of Janus kinase (Jak)– Stat and MAPK pathways. The alpha subunit binds GM-CSF with low affinity, whereas the beta subunit does not bind GM-CSF by itself. Although the cytoplasmic domain of αGMR is short (54 aa), it is essential for cell differentiation, proliferation, and survival induced by GM-CSF. αGMR also appears to have a role independent of βGMR in that αGMR signals for increased glucose transport through activation of phosphatidylinositol 3-kinase.
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