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- 文献和实验
- 技术资料
- 保质期：
Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: <br>2-8°C for 2-7 days under sterile conditions after redissolves; <br>-20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; <br>-20°C to -70℃ for 12 months in lyophilized state.
- 保存条件：
Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: <br>2-8°C for 2-7 days under sterile conditions after redissolves; <br>-20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; <br>-20°C to -70℃ for 12 months in lyophilized state.
- 英文名：
IL-17RA
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ¥520.00 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ¥1560.00 |
| 规格： | 500ug | 产品价格： | ¥6240.00 |
| 规格： | 1mg | 产品价格： | ¥8160.00 |
| 基因名 | IL-17RA |
| 别名 | Interleukin-17 receptor A; IL-17 receptor A; IL-17RA; CDw217; CD_antigen; CD217; IL17RA; IL17R |
| 蛋白号 | Q96F46 |
| 种属 | Human |
| 宿主 | HEK293 |
| 产品描述 | Recombinant Human Interleukin-17 Receptor A is produced by our Mammalian expression system and the target gene encoding Leu33-Trp320 is expressed with a human IgG1 Fc tag at the C-terminus. |
| 区间范围 | Leu33-Trp320 |
| 标签信息 | C-Fc |
| 预测分子量 | 90-120 kDa |
| 表观分子量 | 90-120 KDa, reducing conditions |
| 纯度 | ≥90% by SDS-PAGE. |
| 内毒素 | <1EU/ug as determined by LAL test. |
| 溶剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复溶 | Reconstituted protein solution can be diluted with distilled water. Always centrifuge tubes before opening. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| 储存条件 | Upon receipt, store it immediately at -20°C or lower for long term storage. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: 2-8°C for 2-7 days under sterile conditions after redissolves; -20°C for 1 months and -70℃ for 3 months under sterile conditions after redissolves; -20°C to -70℃ for 12 months in lyophilized state. |
| 运输条件 | 冷冻运输 |
| 背景说明 | Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. |
| 细胞活性 | No activity experimental data, to be verified. |
| ELISA活性 | Immobilized Human IL-17RA-Fc at 2μg/ml (100μl/wel)can bind Anti-Human IL-17RA mAb.The ED50 of Anti-Human IL-17RA mAb is 13.50 ng/ml. |
| SPR/BLI活性 | No activity experimental data, to be verified. |
| 研究领域 | 炎症与免疫调节 |
| 英文名称 | IL-17RA |
| 中文名称 | IL-17RA蛋白 |
| 单位 | 支 |
| 规格 | 10ug ; 50ug ; 500ug ; 1mg |
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文献和实验Immunity：「填补教科书」董晨院士团队解析 IL-17D 重要功能，并首次发现其受体
慢性炎症与自身免疫性疾病、过敏性疾病和肿瘤的发展密切相关，炎性因子白介素 - 17（IL-17）家族在促进宿主防御和自身免疫性疾病中起着重要作用。IL-17 家族由六个成员组成（包括 IL-17A、B、C、D、E、F），IL-17D 是 IL-17 家族中了解最少的成员，其受体也尚不明确。 图片来源：Frontiers in Immunology(1)2021 年 4 月 13 日，清华大学医学院董晨院士团队在 Immunity 上在线发表了题为 Interleukin-17
Quantification of Human IgG and Related Fc Fusion Proteins by a Human IgG/Fc Capture ELISA
of recombinant human IgGs after production and purification for further assays. Here, we describe a human IgG/Fc capture enzyme linked immunosorbent assay (ELISA) which is simple, robust, inexpensive and specific for all types of human IgGs and related Fc fusion
【进展|热点】Immunity:IL-17A和IL-17F的表达调控机制不同
=search&_sort=d&_docanchor=&view=c&_acct=C000057039&_version=1&_urlVersion=0&_userid=2352871&md5=ee0aa845943363c4adec5d48592c918f 无独有偶，10月份的Immunity也发表了一篇文章，指出IL-17A和IL-17F的表达调控机制不同，IL-17A的表达依赖于TCR信号通路。 作者首先发现Itk缺失的Th0细胞能正常分化为Th17细胞后，虽然能正常表达IL-17F、IL-
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