- ￥988 - 21120
- Solarbio
- P00233
- 北京
- 2025年07月25日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
1mg/500ug/50ug/10ug
| 规格： | 1mg | 产品价格： | ￥21120.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥14784.0 |
| 规格： | 50ug | 产品价格： | ￥2600.0 |
| 规格： | 10ug | 产品价格： | ￥988.0 |
| 基本信息 | |
| 基因名 | |
| 别名 | Interleukin-4 receptor subunit alpha;IL-4 receptor subunit alpha;IL-4R subunit alpha;IL-4R-alpha;IL-4RA;CD124;IL-4-binding protein;IL4-BP;IL4R;IL4RA |
| 外观(性状) | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 纯度 | ≥95% as determined by reducing SDS-PAGE. |
| 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 运输条件 | The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 背景说明 | Interleukin 4 Receptor alpha (IL4-Ra) is a widely expressed 140 kDa transmembrane glycoprotein in the class I cytokine receptor family.Mature human IL4-Ra consists of a 207 amino acid (aa) extracellular domain (ECD) that contains a cytokine binding region and one fibronectin type III domain，a 24 aa transmembrane segment，and a 569 aa cytoplasmic domain that contains one Box 1 motif and one ITIM motif.IL4-Ra plays an important role in Th2-biased immune responses，alternative macrophage activation，mucosal immunity，allergic inflammation，tumor progression，and atherogenesis.Soluble forms of IL4-Ra，generated by alternate splicing or proteolysis，retain ligand binding properties and inhibit IL-4 bioactivity.IL4-Ra is a component of two distinct receptor complexes and shows species selectivity between human and mouse.It can associate with the common gamma chain (γc) to form the IL-4 responsive type I receptor in which γc increases the affinity for IL-4 and enables signaling.It can alternatively associate with IL13-Ra1 to form the type II receptor which is responsive to both IL-4 and IL-13.The use of shared receptor components contributes to the overlapping biological effects of IL-4 and IL-13 as well as other cytokines that utilize γc. |
| 来源 | Human cells |
| 溶剂 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 内毒素 | Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test. |
| 单位 | 支 |
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文献和实验Overview of Receptor Allosterism
., Marrs, J., Thomson, F., Cowley, P., Christopoulos, A., Pertwee, R.G., and Ross, R.A. 2005. Allosteric modulation of the cannabinoid CB1 receptor. Mol. Pharmacol. 68:1484‐1495.
Capture and Qualitative Analysis of the Activated Fc Receptor Complex from Live Cells
Bajno, L., Peng, X.R., Schreiber, A.D., Moore, H.P., Trimble, W.S., and Grinstein, S. 2000. Focal exocytosis of VAMP3‐containing vesicles at sites of phagosome formation. J. Cell Biol. 149:697‐706.
Introduction of human 14-3-3 proteins
association of 14-3-3 proteins with Cbl14-3-3 binding sequence in cytoplasmic domain of adhesion receptor,platelet glycoprotein Ib alpha--------------------------------------------------------------------------------14-3-3 brain protein homologs in plantsThe
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