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- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
999
- 靶点：
SOX2
- 级别：
SOX2 Antibody
- 目录编号：
SOX2 Antibody
- 克隆性：
单克隆
- 抗原来源：
小鼠
- 保质期：
SOX2 Antibody
- 抗体英文名：
Alexa Fluor® 647 anti-SOX2 Antibody
- 抗体名：
SOX2 Antibody
- 标记物：
SOX2 Antibody
- 宿主：
小鼠
- 适应物种：
人、小鼠
- 免疫原：
SOX2 Antibody
- 亚型：
SOX2 Antibody
- 形态：
SOX2 Antibody
- 应用范围：
ICC, FC
- 保存条件：
2-8℃
- 浓度：
0.5 mg/ml
- 规格：
100 µg
Description ：SOX2 is the most studied member of SRY-related box transcription factor family. It binds totarget genes through its highly conserved HMG box domain. Inactivation of the SOX2 genecauses lethality during embryonic development. SOX2 knockdown in embryonic stem cellsresults in their differentiation. Co-expression of SOXwith OCT4, MYC, and KLF4 is sufficient toreprogram somatic cells to induced pluripotent stem cells (iPSCs), which exert similarcharacteristics as natural pluripotent stem cells. These findings indicate that SOX2 is crucial forthe self-renewal and pluripotency of embryonic stem cells. In addition, over-expression of SOX2has been found in various types of malignant cancer. Knockdown of SOX2 results in cell cyclearrest by downregulating cyclin D1 and inhibition of tumor cell proliferation, suggesting thatSOX2 is involved in activating genes associated with tumor progression.
Verified Reactivity ：Human, Mouse
Antibody Type ：Monoclonal
Host Species ：Mouse
Immunogen ：Full length human SOX recombinant protein
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation ：The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647under optimal conditions.
Concentration ：0.5 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.
Application ：ICC - Quality tested、FC - Verified
Recommended Usage ：Each lot of this antibody is quality control tested by immunocytochemistry. Forimmunocytochemistry, a concentration range of 1.0 - 5.0 μg/ml is recommended. For flowcytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µlvolume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Excitation Laser ：Red Laser (633 nm)
Application Notes ：This clone is not recommended for ChIP (Chromatin Immunoprecipitation) assays (as determinedby in-house testing).
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文献和实验1. Shrestha R, et al. 2020. Stem Cell Research. 41:101590.. PubMed
2. Shrestha R, et al. 2019. Cells. 8:. PubMed
常用抗体标记荧光染料的选择 随着免疫荧光技术的不断发展，荧光染料及其标记的抗体偶联物也被广泛的应用于生物学实验中。目前，市场上抗体及蛋白标记的荧光染料主要有CFTM系列(BIOTIUM, USA); Alexa Fluor®系列 (Life technology, USA); DyLight系列;Cy系列; IR Dye系列等等。使用最多的为AlexaFluor®系列和CFTM系列。CFTM系列染料的核心对比AlexaFluor®系列具有以下几点优势：1. 新型罗丹明核心罗丹明染料以优异
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HRP、Alexa Fluor® 488、Alexa Fluor® 594 等多种标记一抗可选。 热门可选产品参考 货号 产品名称 类型 加价购价格 S0B0005-25u1 B-actin Rabbit mAb (SDT-RO15) 裸抗 168 元 S0B0004-25u1 B-tubulin Recombinant Rabbit mAb (SDT-RO14) 裸抗 168 元 S0B0383-25u1 S-RMab® Myc tag Recombinant Rabbit
技术原理与方法｜超级色差校正物镜 PLAPON60XOSC 在脑组织四重免疫荧光分析中的应用
种类型的荧光抗体在单个标本中准确展示荧光标记分子的共定位情况。 PLAPON60XOSC 和 UPLSAPO60XO 的性能比较 2. 超级色差校正物镜的应用-脑组织的四重免疫荧光 图 1. 脑组织的四重免疫荧光。 VIAAT 染色（Alexa Fluor405，蓝色）；CB1 染色（Alexa Fluor488，绿色）；VGluT3 染色（Cy3，红色）；DGLα染色（Alexa Fluor647，白色）。 大麻素合成酶 DGLα（白色）和大麻素受体 CB1（绿色）聚集在小鼠
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