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- 详细信息
- 文献和实验
- 技术资料
- 提供商:
上海研匠生物科技有限公司
- 服务名称:
糖尿病模型
- 规格:
只
建模方法:
Wistar大鼠(200-300g)一次性大剂量或多次小伎俩腹腔或静脉注射STZ(60-80mg/kg),72小时后会出现血糖稳定升高、“三多”症状(多饮、多食和多尿)明显,检测血糖在11.1mmol/L时即制成无炎性I型糖尿病。
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文献和实验[1] Weng J, Zhou Z, Guo L, et al. Incidence of type 1 diabetes in China, 2010-13: population based study. BMJ. 2018 Jan 3;360:j5295.
[2] Kachapati K, Adams D, Bednar K, et al. The non-obese diabetic (NOD) mouse as a model of human type 1 diabetes. Methods Mol Biol. 2012;933:3-16.
[3] Mathews CE. Utility of murine models for the study of spontaneous autoimmune type 1 diabetes. Pediatr Diabetes. 2005 Sep; 6(3):165-77.
[4] Al-Awar A, Kupai K, Veszelka M, et al. Experimental Diabetes Mellitus in Different Animal Models. J Diabetes Res. 2016;2016:9051426.
[5] Dhuria RS, Singh G, Kaur A, et al. Current status and patent prospective of animal models in diabetic research. Adv Biomed Res. 2015 May 29;4:117.
[6] Wu J, Yan LJ. Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity. Diabetes Metab Syndr Obes. 2015 Apr 2;8:181-8.
[7] Le May C, Chu K, Hu M, et al. Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9232-7.
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