- 询价
- Cell Signaling Technology
- 3238
- USA
- 2025年08月24日
- W, IP, IHC-P, IHC-F, IF-IC, F
- Rabbit
- H,M,R,Hm,Z,B,Pg
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
Caveolin-1 Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding Glu20 of human caveolin-1
- 应用范围：
W, IP, IHC-P, IHC-F, IF-IC, F
- 宿主：
Rabbit
- 供应商：
CST
- 适应物种：
H,M,R,Hm,Z,B,Pg
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 库存：
大量
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation IHC-P=Immunohistochemistry (Paraffin) IHC-F=Immunohistochemistry (Frozen) IF-IC=Immunofluorescence (Immunocytochemistry) F=Flow Cytometry
Reactivity Key: H=Human M=Mouse R=Rat Hm=Hamster Z=Zebrafish B=Bovine Pg=Pig
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP IHC-P IHC-F IF-IC F | H M R Hm Z B Pg | Endogenous | 21, 24 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Caveolin-1 Antibody detects endogenous levels of caveolin-1 protein. This antibody does not cross-react with caveolin-2 or -3. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu20 of human caveolin-1. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from various cell lines using Caveolin-1 Antibody. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded Non-Hodgkin's lymphoma using Caveolin-1 Antibody. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human lung using Caveolin-1 Antibody. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human colon using Caveolin-1 Antibody. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using Caveolin-1 Antibody. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded 4T1 syngeneic mouse tumor using Caveolin-1 Antibody. IHC-F (frozen)
Immunohistochemical analysis of frozen H1650 xenograft showing cytoplasmic and membrane localization, using Caveolin-1 Antibody. Flow Cytometry
Flow cytometric analysis of HeLa cells using Caveolin-1 antibody (blue) compared to a nonspecific negative control antibody (red). IF-IC
Confocal immunofluorescent analysis of C2C12 cells using Caveolin-1 Antibody (green). Actin filaments have been labeled with Alexa Fluor(R) 555 phalloidin (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). |
| Background | The 21-24 kDa integral proteins, caveolins, are the principal structural components of the cholesterol/sphingolipid-enriched plasma membrane microdomain caveolae. Three members of the caveolin family (caveolin-1, -2, and -3) have been identified with different tissue distributions. Caveolins form hetero- and homooligomers that interact with cholesterol and other lipids (1). Caveolins are involved in diverse biological functions, including vesicular trafficking, cholesterol homeostasis, cell adhesion, and apoptosis, and are also implicated in neurodegenerative disease (2). Caveolins interact with multiple signaling molecules, such as Gα subunit, tyrosine kinase receptors, PKCs, Src family tyrosine kinases, and eNOS (1,2). It is believed that caveolins serve as scaffolding proteins for the integration of signal transduction. Phosphorylation at Tyr14 is essential for caveolin association with SH2 or PTB domain-containing adaptor proteins, such as GRB7 (3-5). Phosphorylation at Ser80 regulates caveolin binding to the ER membrane and entry into the secretory pathway (6).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Role of Caveolin-1 in the Regulation of Pulmonary Endothelial Permeability
pulmonary vascular hyperpermeability and protein-rich edema formation. Moreover, caveolin-1, a structural and scaffolding protein required for caveolae formation and transcellular transport, also plays an important role in oxidant-induced paracellular
Mapping of Oxidative Stress Response Elements of the Caveolin-1 Promoter
to organismal aging. The molecular mechanisms that mediate the cellular response to oxidants remain to be fully identified. We have shown that oxidative stress induces cellular senescence through activation of the caveolin-1 promoter and upregulation of caveolin-1
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
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