- 询价
- Cell Signaling Technology
- 2774
- USA
- 2025年08月09日
- W, IP, IHC-P
- Rabbit
- H,Mk
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
Bax Antibody (Human Specific)
- 抗原：
synthetic peptide corresponding to residues surrounding lysine 58 of human Bax
- 应用范围：
W, IP, IHC-P
- 宿主：
Rabbit
- 适应物种：
H,Mk
- 保质期：
详见说明书
- 供应商：
CST
- 级别：
详见MSDS文件
- 库存：
大量
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key: H=Human Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP IHC-P | H Mk | Endogenous | 20 | Rabbit |
| Protocols | |
|---|---|
| Specificity / Sensitivity | Bax Antibody (Human-Specific) detects endogenous levels of total Bax protein. Cross-reativity was not detected with other family members at physiological conditions. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding lysine 58 of human Bax. Antibodies were purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from 293, HT-1080 and Raji cell lines using Bax Antibody #2772 (left) and Bax Antibody (Human Specific) #2774 (right). IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using Bax Antibody (Human Specific). IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human Non-Hodgkin's lymphoma using Bax Antibody (Human Specific). |
| Background | Bax is a key component for cellular induced apoptosis through mitochondrial stress (1). Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane (2). Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis (3,4). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Symplex™ is an antibody discovery technology that identifies fully human antigen-specific antibody repertoires directly from plasma cells. The technology utilizes reverse transcription and overlap extension polymerase chain reaction performed
Screening of Antigen-Specific Antibody-Secreting Cells
biology is recently used to obtain antigen-specific human monoclonal antibodies. Here, we describe the new method for screening antigen-specific antibody-secreting cells at single-cell levels using microwell-array chips. The system can be applied to screen
a simple ELISA method to detect human anti-antibody response.
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