神经肽VIP和PACAP防止活化T细胞凋亡通路图

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细胞凋亡专题

<center> <img alt="神经肽VIP和PACAP防止活化T细胞凋亡通路图" height="456" src="http://img.dxycdn.com/trademd/upload/asset/meeting/2013/08/27/A1377590748.gif" width="540" /></center> <center>  </center>

Vasoactive intestinal peptide (VIP) and the structurally related pituitary adenylate cyclase-activating polypeptide (PACAP), two neuropeptides present in the lymphoid microenvironment, elicit a broad spectrum of biological functions, including the modulation of innate and adaptive immunity. Another important immunoregulatory function of VIP and PACAP is their inhibition effect on AICD in T cells. They inhibit the TCR-stimulated FasL expression and apoptosis of T cell through specific receptors and induction of intracellular cAMP. VIP down-regulate c-Myc synthesis, the NF-AT-dependent Egr2 and Egr3 expression, the NF-AT and NF-kB.