Expression of Neurotrophic Factors such as GDNF in the E. coli System
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Neurotrophic factors play an essential role in the growth, survival, and differentiation of neurons in the nervous system.
Several well-characterized neurotrophic factors, such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF),
neurotrophin-3 (NT-3), NT-4/5, glial-cell-line-derived neurotrophic factor (GDNF), ciliary neurotrophic factor (CNTF), insulin-like
growth factor-1 (IGF-I), are currently in clinical trials and have potential for the treatment of neurological diseases.
