Transgenic Expression of Neurotrophic Factors and Their Receptors
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The finding that nerve growth factor (NGF) influences the survival and maintenance of only selective neuronal populations has led to the identification of many related polypeptide factors, constituting a family of neurotrophic factors. Since NGF is required for neural crest-derived sensory and sympathetic neurons at precise periods during development and also influences cholinergic neurons in the basal forebrain, it became clear that other neuronal populations must rely on other distinctive growth factors (Thoenen and Barde, 1980; Barde, 1990).
