• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Effects of the β-Amyloid Peptide on Membrane Ion Permeability

        互联网

        481
        Several lines of evidence suggest a role for membrane ion channels in the neurotoxic effects of the β-amyloid peptide (Aβ). This chapter describes the electrophysiological techniques that can be employed to isolate and record specific membrane conductances that may be altered by Aβ. In general, an increase in conductances that cause depolarization of the cell membrane may be considered excitotoxic since they will: (1 ) increase Ca2+ influx through voltage-gated Ca2+ channels and (2) reduce Mg2+ -dependent block of ionotropic glutamate receptors, thereby increasing Ca2+ influx through N -methyl-D-aspartate (NMDA) receptor channels. Conversely, an increase in conductances that cause membrane hyperpolarization might be considered to have a protective effect. This is a simplistic view, as it has been shown that for certain forms of apoptosis an increase in hyperpolarizing K+ currents may be involved (1 ). It is, therefore, important to consider the functional effects of any changes in membrane conductances or ion channel currents induced by Aβ in the light of neurotoxic effects of the peptide.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序