- ￥4800
- Tanda
- 美国
- TD-26235
- 2025年10月30日
- ELISA, WB
- Mouse
- 脊椎动物
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
A synthetic peptide from the internal region of EGFR which includes the deletion of E746-A750, human origin.
- 亚型：
lgG
- 形态：
液体
- 保存条件：
-20℃
- 克隆性：
单克隆
- 标记物：
FITC
- 适应物种：
脊椎动物
- 保质期：
24个月
- 抗原来源：
蛋白
- 目录编号：
TD-26235
- 级别：
科研级
- 库存：
999
- 供应商：
武汉天德
- 宿主：
Mouse
- 应用范围：
ELISA, WB
- 浓度：
1mg/ml
- 靶点：
E746-A750
- 抗体英文名：
Anti-EGFR (E746-A750)del mouse monoclonal antibody
- 抗体名：
EGFR(E746-A750)del
- 规格：
100 μL
EGFR(E746-A750)del
| Cat. #: TD-26235 |
| Gene Symbol: EGFR/HER1/ERBB1 |
| Description: Anti-EGFR(E746-A750)del Mouse Monoclonal Antibody |
| Background: EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. Defects in EGFR are associated with lung cancer (LNCR). |
| Immunogen: A synthetic peptide from the internal region of EGFR which includes the deletion of E746-A750, human origin. |
| Applications: ELISA, WB |
| Recommended Dilutions: ELISA: 1:1000-1:5000 WB: 1:500-1:1000 |
| Concentration: 1 mg/ml |
| Host Species: Mouse |
| Format: Liquid |
| Clonality: Monoclonal |
| Isotype: |
| Purity: Purified from ascites |
| Preservative: No |
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Species Reactivity: Recognizes EGFR(E746-A750), but not wild type EGFR of vertebrates. |
| Storage Conditions: Store at -20°C. Avoid freeze/thaw cycles |
Western blot:
Western blot analysis of recombinant EGFR(E746-A750) and wild type proteins.
Purified His-tagged EGFR(E746-A750)del protein (aa 702-987) and wild type protein (aa 702-987) were blotted with anti- EGFR(E746-A750)del mouse antibody (Cat. #TD-26235).
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文献和实验strategies. EGFR mutation profiling assesses gefitinib or erlotinib efficacy in non-small cell lung cancer patients. Tumor genotyping of multiple genes and/or mutations, however, is not widely deployed due to the high cost of analyzing these regions
Selecting, Acquiring, and Using Small Molecule Libraries for High‐Throughput Screening
solubility and permeability in drug discovery and development settings. Adv. Drug Del. Rev. 46:3‐26. Lovering, F., Bikker, J., and Humblet, C. 2009. Escape from flatland
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