- ￥4800
- Tanda
- 美国
- TD-26290
- 2025年10月27日
- ELISA, WB
- Mouse
- 脊椎动物
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
A synthetic peptide from the internal region of ALK which includes the mutation of D1225N, human origin.
- 亚型：
lgG
- 形态：
液体
- 保存条件：
-20℃
- 克隆性：
单克隆
- 标记物：
FITC
- 适应物种：
脊椎动物
- 保质期：
24个月
- 抗原来源：
蛋白
- 目录编号：
TD-26290
- 级别：
科研级
- 库存：
999
- 供应商：
武汉天德
- 宿主：
Mouse
- 应用范围：
ELISA, WB
- 浓度：
1mg/ml
- 靶点：
D1225N
- 抗体英文名：
Anti-ALK (D1225N) mouse monoclonal antibody
- 抗体名：
ALK(D1225N)
- 规格：
100 μL
ALK(D1225N)
| Cat. #: TD-26290 |
| Gene Symbol: ALK, CD246, NBLST3 |
| Description: Anti-ALK(D1225N) Mouse Monoclonal Antibody |
| Background: Anaplastic lymphoma kinase (ALK) also known as CD246 (cluster of differentiation 246) is a tyrosine kinase receptor that plays an important role in the development of the brain and nervous systems. Deficiencies in ALK, which most commonly as a fusion with other genes, are indicated in cancers. |
| Immunogen: A synthetic peptide from the internal region of ALK which includes the mutation of D1225N, human origin. |
| Applications: ELISA, WB |
| Recommended Dilutions: ELISA: 1:1000-1:5000 WB: 1:500-1:2000 |
| Concentration: 1 mg/ml |
| Host Species: Mouse |
| Format: Liquid |
| Clonality: Monoclonal |
| Isotype: IgG |
| Purity: Purified from ascites |
| Preservative: No |
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Species Reactivity: Recognizes D1225N mutant, but not wild type ALK of vertebrates. |
| Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
| Western blot:
Western blot analysis of recombinant ALK(D1225N) and wild type proteins. Purified His-tagged ALK(D1225N) protein (1060-1620aa, 68KD, lane 2) and corresponding wild type protein (lane 1) were blotted with Anti-ALK(D1225N) monoclonal antibody (Cat. #TD-26290). |
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文献和实验肺癌病人的诊断和个性化治疗提供了有效的筛查工具。同样，以ROS1融合蛋白抗体（克隆号D4D6，货号#3287）为基础的IHC检测技术与断裂FISH方法相比，在非小细胞肺癌上IHC检测的准确度达到100%【5】。如此，我们期待检测ROS1融合变异的临床诊断用IHC试剂盒不久将成功推出。如要了解更多有关ALK和ROS1抗体的验证数据，请点击：ALK (D5F3) XP®Rabbit mAb #3633 和 ROS1 (D4D6) Rabbit mAb #3287。 本文
sunnyhaipo 各位大侠好，我是个实验的初学者。有个问题想求大家的帮助。我想检测一下石蜡标本中是否存在ALK融合基因的表达。ALK基因位于2p23,好像有6000多dp，ALK基因的多个外显子之间通常会有一些其他的基因融合其中从而会产生致瘤作用的融合蛋白。目前发现的可能会与ALK基因融合的其他基因有10来种，我想问一下怎样能够检测标本中是否存在这些融合基因的表达。我查过一些文献，有用FISH的，有用特异探针PCR的，有用免疫组化检测融合蛋白表达的，有用
Identification of O-linked -d-N-acetylglucosamine-Modified Proteins from Arabidopsis
The posttranslational modification of proteins with O-linked β-d -N -acetylglucosamine (O-GlcNAc) on serine and threonine residues occurs in all animals and plants. This modification is dynamic and ubiquitous, and regulates many cellular
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