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Chromatin immunoprecipitation: optimization, quantitative analysis and data normalization

, rather than by changes in histone modification levels. Histone modifications can only be detected at a specific DNA sequence region if this region is also wrapped into nucleosomes. For example, a relatively low H3K4me2 signal at the transcription start site of a gene

Whole genome amplification protocol for ChIP-chip

-chip assay) allows a global analysis of binding sites for transcription factors and components of the transcriptional machinery, as well as of chromatin modification patterns. However, a single ChIP sample does not yield enough DNA for hybridization