Puromycin (hydrochloride)

蛋白质合成抑制剂；体外抑制蛋白质合成99%；PSA和APN抑制剂（IC50s分别为9.7和41µM）；降低HL-60和MOLT-4细胞活力（EC50s分别为0.055和0.17µM）；对氯喹敏感和抗性的恶性疟原虫T9-96和K1菌株有效（IC50s分别为0.024和0.023µM）；已用作细胞培养系统中的选择性标记，并经过化学修饰用于标记或成像新合成的蛋白质。An inhibitor of protein synthesis; inhibits protein synthesis by 99% in vitro; an inhibitor of PSA and APN (IC50s = 9.7 and 41 µM, respectively); reduces viability of HL-60 and MOLT-4 cells (EC50s = 0.055 and 0.17 µM, respectively); active against the chloroquine-sensitive and -resistant P. falciparum strains T9-96 and K1 (IC50s = 0.024 and 0.023 µM, respectively); has been used as a selective marker in cell culture systems and has been chemically modified for use in labeling or imaging newly synthesized proteins.