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- T2604
- 10045-45-1
- 2025年08月03日
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- 保存条件：
1-EBIO/1-Ethyl-2-benzimidazolinone
- 供应商：
10045-45-1
- 库存：
T2604
- CAS号：
10045-45-1
- 英文名：
1-EBIO/1-Ethyl-2-benzimidazolinone
- 规格：
25MG
1-EBIO/1-Ethyl-2-benzimidazolinone
产品编号 T2604 CAS 10045-45-1
别名: 1-EBIO
1-Ethyl-2-benzimidazolinone 是一类钙离子敏感的钾离子通道激动剂。它可研究在多种生理功能中钾离子通道的作用。
1-Ethyl-2-benzimidazolinone 是一类钙离子敏感的钾离子通道激动剂。它可研究在多种生理功能中钾离子通道的作用。
溶解度
DMSO: 60 mg/mL (369.93 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
溶液配制表
| 浓度 体积 质量 |
| 1 mg | 5 mg | 10 mg | 50 mg | |
| 1 mM | 6.1656 mL | 30.828 mL | 61.6561 mL | 308.2804 mL |
| 5 mM | 1.2331 mL | 6.1656 mL | 12.3312 mL | 61.6561 mL |
| 10 mM | 0.6166 mL | 3.0828 mL | 6.1656 mL | 30.828 mL |
| 50 mM | 0.1233 mL | 0.6166 mL | 1.2331 mL | 6.1656 mL |
| 产品描述 | 1-Ethyl-2-benzimidazolinone is a calium channel agonist. |
| 激酶实验 | Procedures for BTK OMNIA Assay: The Omnia continuous read assay is performed essentially as described by the vendor. The assay conditions are: 40 μM ATP (1X KMATP), 10 μM Y5-Sox, and 10 nM BTK enzyme. Briefly, a substrate mix containing 1.13X ATP and the Y5 Sox substrate is first prepared in 1X Omnia Kinase Reaction Buffer (KRB) consisting of 20 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EGTA, 5 mM?β-glycerophosphate, 5% glycerol, and 0.2 mM DTT. For IC50 measurements, 5 μL of enzyme are incubated with serially diluted (3-fold) compounds prepared in 50% DMSO in a Corning (#3574) 384-well, white, non-binding surface microtiter plate at 25°C for 30 min. Kinase reactions are started with the addition of 45 μL of the ATP/Y5 substrate mix and monitored at λex360/λem485 in a Synergy 4 plate reader for 60 minutes. Progress curves from each well are examined for linear reaction kinetics and fit statistics. Initial velocity from each reaction is determined from the slope of a plot of relative fluorescence units versus time and then plotted against inhibitor concentration to estimate IC50 using the Response, Variable Slope model in Graph Pad Prism from Graph Pad Software. |
| 别名 | 1-EBIO |
| 分子量 | 162.19 |
| 分子式 | C9H10N2O |
| CAS No. | 10045-45-1 |
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1-EBIO/1-Ethyl-2-benzimidazolinone
￥2117
