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- 2026年02月28日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 英文名：
alpha-Galactosylceramide [alpha-Gal-Cer; KRN7000]
- 保质期：
见包装说明
- 保存条件：
4°C
- 库存：
99
- 供应商：
欣博盛生物
- 规格：
250 ug/1 mg/5 mg
| 规格： | 250 ug | 产品价格： | ￥1320.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1920.0 |
| 规格： | 5 mg | 产品价格： | ￥7680.0 |
alpha-Galactosylceramide [alpha-Gal-Cer; KRN7000]产品货号AG-CN2-0013，由Adipogen公司研发生产，欣博盛生物是Adipogen公司授权一级代理商，如需购买Adipogen公司产品，技术问题，请联系欣博盛生物。热销品常备现货~
Synonyms KRN7000; α-Gal-Cer; αGalCer; alphaGalCer; α-GC
Product Type Chemical
Properties
Formula
C50H99NO9
MW 858.3
CAS 158021-47-7
Source/Host Chemicals Synthetic. Originally isolated from the marine sponge Agelas mauritianus.
Purity Chemicals ≥98% (NMR, TLC (CHCl3/MeOH 85:15))
Appearance White to off-white solid.
Solubility Soluble in pyridine. Solubilization in Tween20 or PBS for cell culture use see online protocol.
Identity Identity determined by 1H-NMR.
Declaration Manufactured by AdipoGen. Not sold in Japan.
InChi Key LSUQVAFARUJTHS-ABBGRRHVSA-N
Smiles [H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].[H].CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](COC1OC(CO)C(O)C(O)C1O)NC(=O)CC#CC#CC#CC#CC#CC#CC#CC#CC#CC#CC#CC#C
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Aliquot into glass vials.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
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- 作者
- 内容
- 询问日期
文献和实验- Synthesis of alpha-, beta-monoglycosylceramides and four diastereomers of an alpha-galactosylceramide: M. Morita, et al.; Bioorg. Med. Chem. Lett. 5, 699 (1995)
- Immunostimulatory and antitumor activities of monoglycosylceramides having various sugar moieties: K. Motoki, et al.; Biol. Pharm. Bull. 18, 1487 (1995)
- Immunostimulatory activities of monoglycosylated alpha-D-pyranosylceramides: A. Uchimura, et al.; Bioorg. Med. Chem. 5, 2245 (1997)
- Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein: Fujii S, et al.; J. Exp. Med. 198, 267 (2003)
- Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides: K.O. Yu, et al.; PNAS 102, 3383 (2005)
- A phase I study of alpha-galactosylceramide (KRN7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lung cancer: A. Ishikawa, et al.; Clin. Cancer Res. 11, 1910 (2005)
- Pivotal advance: alpha-galactosylceramide induces protection against lipopolysaccharide-induced shock: G. Sireci, et al.; J. Leukoc. Biol. 81, 607 (2007)
- α-Galactosylceramide activates antitumor immunity against liver tumor: T. Tatsumi, et al.; Hepatol. Res. 41, 160 (2011)
- Deletion of CD1d in adipocytes aggravates adipose tissue inflammation and insulin resistance in obesity: J.Y. Huh, et al.; Diabetes 66, 835 (2017)
- Migration, Distribution, and Safety Evaluation of Specific Phenotypic and Functional Mouse Spleen-Derived Invariant Natural Killer T2 Cells after Adoptive Infusion: Mediators Inflamm. 5170123 (2021)
- Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice: S.M. Han, et al.; Nature Commun. 14, 8512 (2023)
-CN2-0013-C250 alpha-Galactosylceramide [alpha-Gal-Cer; KRN7000] α-半乳糖神经酰胺，NK 细胞激活剂 250 ug BML-SL232-0100 KRN7000 α-半乳糖神经酰胺 100 ug
Replication timing by density transfer
), arrest with 200 nM alpha factor (1-1.25 doubling times, until % unbudded cells stops increasing). NOTE: This alpha factor concentration is for bar1 strains. BAR1+ strains require 15x more alpha factor. 3. Filter, wash in Ycomp+alpha factor, resuspend
Replication timing by comparative hybridization
cells per time point. (Raffinose has not worked well for me, so I avoid it.) 2. Arrest the culture with alpha factor (200 nM final concentration for bar1 strains) when the OD660 is about 0.2-0.25. 3. When the cells have arrested (more than 95
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