- ￥1500 - 4500
- Adipogen
- 瑞士
- AG-CN2-0118-C250
- 2026年02月28日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 英文名：
Heptelidic acid
- 保质期：
见包装说明
- 保存条件：
4°C
- 库存：
99
- 供应商：
欣博盛生物
- 规格：
250 ug/1 mg
| 规格： | 250 ug | 产品价格： | ￥1500.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥4500.0 |
Heptelidic acid产品由Adipogen公司生产，产地是瑞士。该产品货号为AG-CN2-0118-C250，包装规格是250 ug。如需购买该产品，询问折扣价/货期/技术问题，请联系Adipogen授权代理商——欣博盛生物
Synonyms Koningic acid; Avocettin; FO-4443; BRN 5091359; HPA
Product Type Chemical
Properties
Formula
C15H20O5
MW 280.3
CAS 57710-57-3 (74310-84-2 deleted)
Source/Host Chemicals Isolated from Trichoderma sp.
Purity Chemicals ≥95% (HPLC)
Appearance White solid.
Solubility Soluble in DMSO (10mg/ml), ethanol (1mg/ml), methanol (1mg/ml) or water (1mg/ml).
InChi Key JESMSCGUTIEROV-RTWAVKEYSA-N
Smiles [H][C@@]12C=C(COC(=O)[C@@]1([H])[C@@]1(CO1)CC[C@H]2C(C)C)C(O)=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 3 years after receipt when stored at -20°C.
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验- A new sesquiterpene antibiotic, heptelidic acid producing organisms, fermentation, isolation and characterization: Y. Itoh, et al.; J. Antibiot. (Tokyo) 33, 468 (1980)
- Structure of heptelidic acid, a new sesquiterpene antibiotic from fungi: Y. Itoh, et al.; J. Antibiot. (Tokyo) 33, 525 (1980)
- Specific inhibition of glyceraldehyde-3-phosphate dehydrogenase by koningic acid (heptelidic acid): A. Endo, et al.; J. Antibiot. (Tokyo) 38, 920 (1985)
- Inactivation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase by koningic acid: K. Sakai, et al.; Biochim. Biophys. Acta 952, 297 (1988)
- Identification of koningic acid (heptelidic acid)-modified site in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase: K. Sakai, et al.; Biochim. Biophys. Acta 1077, 192 (1991)
- Koningic acid (heptelidic acid) inhibition of glyceraldehyde-3-phosphate dehydrogenases from various sources: M. Kato, et al.; Biochim. Biophys. Acta 1120, 113 (1992)
- Glyceraldehyde-3-phosphate dehydrogenase is required for the transport of nitric oxide in platelets: B. McDonald, et al.; PNAS 90, 11122 (1993)
- Antitumor activity of heptelidic acid chlorohydrin: J. Kawashima, et al.; J. Antibiot. (Tokyo) 47, 1562 (1994)
- Antimalarial activity of radicicol, heptelidic acid and other fungal metabolites: Y. Tanaka, et al.; J. Antibiot. (Tokyo) 51, 153 (1998)
- Glyceraldehyde-3-phosphate dehydrogenase activity as an independent modifier of methylglyoxal levels in diabetes: P.J. Beisswenger, et al.; Biochim. Biophys. Acta 1637, 98 (2003)
- D-Glyceraldehyde causes production of intracellular peroxide in pancreatic islets, oxidative stress, and defective beta cell function via non-mitochondrial pathways: H. Takahashi, et al.; J. Biol. Chem. 279, 37316 (2004)
- Glucose-dependent active ATP depletion by koningic acid kills high-glycolytic cells: S. Kumagai, et al.; BBRC 365, 362 (2008)
- Heptelidic acid, a sesquiterpene lactone, inhibits Etoposide-induced apoptosis in human leukemia U937 cells: J.H. Kim & C.H. Lee; J. Microbiol. Biotechnol. 19, 787 (2009)
- Novel terpenoids, trichoderonic acids A and B isolated from Trichoderma virens, are selective inhibitors of family X DNA polymerases: Y. Yamaguchi, et al.; Biosci. Biotechnol. Biochem. 74, 793 (2010)
- Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch: P. M. Gubser, et al.; Nat. Immunol. 14, 1064 (2013)
- The immune-metabolic basis of effector memory CD4+ T cell function under hypoxic conditions: S. Dimeloe, et al.; J. Immunol. 196, 106 (2016)
- ATP produced by anaerobic glycolysis is essential for enucleation of human erythroblasts: T. Goto, et al.; Exp. Hematol. 72, 14 (2019)
- Probiotic Aspergillus oryzae produces anti-tumor mediator and exerts anti-tumor effects in pancreatic cancer through the p38 MAPK signaling pathway: H. Konishi, et al.; Nat. Sci. Rep. 11, 11070 (2021)
- Plasmacytoid dendritic cell activation is dependent on coordinated expression of distinct amino acid transporters: K.M. Grzes, et al.; Immunity 54, 2514 (2021)
- Probiotic-derived heptelidic acid exerts antitumor effects on extraintestinal melanoma through glyceraldehyde-3-phosphate dehydrogenase activity control: S. Isozaki, et al.; BMC Microbiol. 22, 110 (2022)
β-咪唑丙烯酸。给予狗大量的组氨酸后可从尿中得到，还有细菌作用于组氨酸也能生成尿刊酸。在哺乳类的肝脏或细菌中作为从组氨酸到谷氨酸的代谢途径的中间体，在组氨酸酶的作用下进行分子内的无氧脱氨基而生成。通常尿刊酸在肝脏酶（尿刊酸酶）的作用下进一步分解转变成谷氨酸。
C24 H40 O5 3α， 7α， 12α三羟基 -5 β胆烷酸，是广泛分布于以人为首的脊椎动物中的最主要的胆汁酸。在胆汁中，以与甘氨酸或牛磺酸结合成甘胆酸（ glycocholic acid）或牛磺胆酸的形态存在。
α -羟基丙酸。 L型（见图）为厌氧糖酵解的最终产物，是由乳酸脱氧酶的作用使丙酮酸还原而生成的。在激烈的肌肉运动时，乳酸在肌肉中积累，其一部分随血液流到肝脏，再合成为葡萄糖（糖的产生）。在乳酸菌的乳酸发酵和大肠杆菌、梭状芽胞杆菌属的混合有机酸发酵过程中也能大量形成乳酸，为酸乳酪（ yoghurt）和咸菜的酸味的主要成分。这里因生物种类不同，有时可产生 L型、 D型和外消旋体。在动物和微生物中是作为碳源而被利用的物质之一。
技术资料暂无技术资料 索取技术资料
