- ￥2520 - 4680
- Adipogen
- 瑞士
- AG-40A-0081-C050
- 2026年03月02日
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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
Jagged-1 (human):Fc (human) (rec.)
- 保质期：
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
- 保存条件：
-20°C
- 库存：
99
- 供应商：
欣博盛生物
- 规格：
50 ug/10 ug
| 规格： | 50 ug | 产品价格： | ￥4680.0 |
|---|---|---|---|
| 规格： | 10 ug | 产品价格： | ￥2520.0 |
Jagged-1 (human):Fc (human) (rec.)产品由Adipogen公司生产，产地是瑞士。该产品货号为AG-40A-0081-C050，包装规格是50 ug。如需购买该产品，询问折扣价/货期/技术问题，请联系Adipogen授权代理商——欣博盛生物
Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).
Synonyms Protein Jagged-1; hJ1; CD339; JAG1
Product Type Protein
Properties
Source/Host HEK 293 cells
Sequence
Signal peptide and extracellular domain of human Jagged-1 (HJ1; CD339) (aa 1-1067) are fused at the C-terminus to the Fc portion of human IgG1.
Crossreactivity Human
Biological Activity
Inhibits adipogenesis of mesenchymal stem cells (MSCs). Induces Hes-1 in 3T3L-1 cells.
MW ~150kDa (SDS-PAGE)
Purity ≥90% (SDS-PAGE)
Endotoxin Content <0.1EU/μg purified protein (LAL test; Lonza).
Concentration 0.5mg/ml
Formulation Liquid. 0.2μm-filtered solution in PBS.
Protein Negative Control
Fc (human) IgG1 Control (rec.)
Other Product Data
Uniprot link P78504: Jagged-1 [Precursor]
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After opening, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
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文献和实验- Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi): S.M. Thakurdas, et al.; Hepatology 63, 550 (2016)
- Single factors alone can induce mesenchymal-like morphology, but not promote full EMT in breast cancer cell lines with different hormone statuses: M.K. Tveitaras, et al.; Exp. Cell Res. 359, 257 (2017)
- Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity: H. Sakai, et al.; PLoS ONE 12, e0177516 (2017)
Quantification of Human IgG and Related Fc Fusion Proteins by a Human IgG/Fc Capture ELISA
of recombinant human IgGs after production and purification for further assays. Here, we describe a human IgG/Fc capture enzyme linked immunosorbent assay (ELISA) which is simple, robust, inexpensive and specific for all types of human IgGs and related Fc fusion
consists of a cooperation between monocytes and cytophilic antibodies able to bind to the Fc receptors present on the monocyte surface. Thus human IgG1 and IgG3 are the main isotypes effective in ADCI, whereas IgG2, IgG4, and IgM are ineffective
The Human Mast Cell: An Overview
lymphocytes, and their granule contents. Mast cells can undergo activation by antigens/allergens (acting via the high-affinity receptor for immunoglobulin E, also referred to as FcεRI), superoxides, complement proteins, neuropeptides, and lipoproteins
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