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Progranulin (human) (rec.) (un

tagged)
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  • ¥2400 - 5640
  • Adipogen已认证
  • 瑞士
  • 2026年03月03日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 英文名

      Progranulin (human) (rec.) (untagged)

    • 保质期

      见包装说明

    • 保存条件

      4°C

    • 库存

      99

    • 供应商

      欣博盛生物

    • 规格

      50 ug/10 ug

    规格:50 ug产品价格:¥5640.0
    规格:10 ug产品价格:¥2400.0

    Progranulin (human) (rec.) (untagged)产品由Adipogen公司生产,产地是瑞士。该产品货号为AG-40A-0188Y-C050,包装规格是50 ug。如需购买该产品,询问折扣价/货期/技术问题,请联系Adipogen授权代理商——欣博盛生物 

    Synonyms    Proepithelin; PEPI; PC Cell-derived Growth Factor
    Product Type    Protein
    Properties
    Source/Host    HEK 293 cells
    Sequence    
    Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa.

    Crossreactivity    Human
    Biological Activity    
    Binds to human sortilin. Activates phospho-ERK1/2 in neuronal mouse P19 cells. Regulates food intake and body weight (see reference 1).

    MW    ~90kDa (glycosylated protein by SDS-PAGE)
    Purity    ≥98% (SDS-PAGE)
    Endotoxin Content    <0.01EU/μg purified protein (LAL test; Lonza).
    Concentration    After reconstitution:
    for 10µg size: 0.1mg/ml
    for 50µg size: 1 mg/ml
    Reconstitution    10µg size: Reconstitute with 100µl sterile endotoxin-free water.
    50µg size: Reconstitute with 50µl sterile endotoxin-free water.
    Formulation    Lyophilized. Contains PBS.
    Other Product Data    
    Uniprot link P28799: Granulins (human) [Precursor]

    Shipping and Handling
    Shipping    BLUE ICE
    Short Term Storage    +4°C
    Long Term Storage    -20°C
    Handling Advice    After reconstitution, prepare aliquots and store at -20°C.
    Avoid freeze/thaw cycles.
    Centrifuge lyophilized vial before opening and reconstitution.
    PBS containing at least 0.1% BSA should be used for further dilutions.
    Use/Stability    Stable for at least 6 months after receipt when stored at -20°C.
    Working aliquots are stable for up to 3 months when stored at -20°C.

     

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    图标文献和实验
    该产品被引用文献
    1. Involvement of Progranulin in Hypothalamic Glucose Sensing and Feeding Regulation: H.K. Kim, et al.; Endocrinology 152, 4672 (2011)
    2. Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains: J. Jian, et al.; FEBS Lett. 587, 3428 (2013)
    3. Progranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor B (RANK)-dependent formation of multinucleated osteoclasts: J. Oh, et al.; J. Biol. Chem. 290, 2042 (2015)
    4. New discovery rarely runs smooth: an update on progranulin/TNFR interactions: B.C. Wang, et al.; Protein Cell 6, 792 (2015)
    5. Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes: Y. Tanaka, et al.; Hum. Mol. Genet. 26, 969 (2017)
    6. SorCS2 binds progranulin and regulates motor axon outgrowth: PB. Thomasen, et al.; Cell Rep. 42, 113333 (2023)
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    文献支持
    Progranulin (human) (rec.) (untagged)
    ¥2400 - 5640