- 询价
- Cell Signaling Technology
- 4263
- USA
- 2025年12月13日
- W, IP
- H,M,R,Mk
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
PI3 Kinase Class III (D9A5) Rabbit mAb
- 抗原：
synthetic peptide surrounding Lys630 of human PI3 kinase class III
- 应用范围：
W, IP
- 适应物种：
H,M,R,Mk
- 库存：
大量
- 保质期：
详见说明书
- 级别：
详见MSDS文件
- 供应商：
CST
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IP | H M R Mk | Endogenous | 100 | Rabbit IgG |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | PI3 Kinase Class III (D9A5) Rabbit mAb detects endogenous levels of total PI3K class III protein. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide surrounding Lys630 of human PI3 kinase class III. Western Blotting
Western blot analysis of extracts from mouse brain and C6 cells using PI3 Kinase Class III (D9A5) Rabbit mAb. |
| Background | Three distinct types of phosphoinositide 3-kinases (PI3K) have been characterized. Unlike other PI3Ks, PI3K class III catalyzes the phosphorylation of phosphatidylinositol at the D3 position, producing phosphatidylinositol-3-phosphate (PIP3) (1). PI3K class III is the mammalian homolog of Vps34, first identified in yeast. PI3K class III interacts with the regular subunit p150, the mammalian homolog of Vps15, which regulates cellular membrane association through myristoylation (2,3). PIP3 recruits several proteins with FYVE or PX domains to membranes regulating vesicular transport and protein sorting (4). Moreover, PI3K class III has been shown to regulate autophagy, trimeric G-protein signaling, and the mTOR nutrient-sensing pathway (5). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Measurement of Phosphoinositide 3-Kinase Activity
adaptor molecule ( 1 ). The class II PI 3-kinases are characterized by the presence of a C-2 domain at the carboxy terminus and utilize predominantly PtdIns and PtdIns(4)P as substrates (e.g., PI3K-C2α), whereas the class III PI 3-kinases utilize
化锂）：IMPase 抑制剂（即Inositol monophosphatase，肌醇单磷酸酶） 3）Earle's平衡盐溶液：制造饥饿 4）N-Acetyl-D-sphingosine（C2-ceramide）：Class I PI3K Pathway抑制剂 5）Rapamycin：mTOR抑制剂 6）Xestospongin B/C：IP3R阻滞剂 （二）自噬抑制剂 1）3-Methyladenine（3-MA）：（Class III PI3K） hVps
三句话读懂一篇 CNS，首次揭示从鱼进化到人的演变机制，运动能帮助人体对抗慢性炎症...
phosphoinositide 3-kinase signaling to bolster T cell immunity，该研究利用不同的小鼠基因模型和大量的体外生化实验，将 Warburg 效应和细胞中 PI3K 激酶的活性串联起来，证明 伴随着急剧增长的细胞快速地向 Warburg 效应的转向，PI3K 激酶的活性也随之增加，从而加快细胞分裂进程。 该研究颠覆了被学术界普遍认同的观点，即新陈代谢是细胞信号指导下的次级活动。科学研究永无止境，时间会验证一切真理！ 图 10：来源 Science 9. Science
技术资料暂无技术资料 索取技术资料
