- 询价
- Cell Signaling Technology
- 3528
- USA
- 2025年12月06日
- W, IP, IHC-P, IF-IC, F
- H
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 抗体英文名：
CD31 (PECAM-1) (89C2) Mouse mAb
- 抗原：
recombinant human CD31 protein
- 应用范围：
W, IP, IHC-P, IF-IC, F
- 适应物种：
H
- 供应商：
CST
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 库存：
大量
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation IHC-P=Immunohistochemistry (Paraffin) IF-IC=Immunofluorescence (Immunocytochemistry) F=Flow Cytometry
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IP IHC-P IF-IC F | H | Endogenous | 130 | Mouse IgG2b |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | CD31 (PECAM-1) (89C2) Mouse mAb detects endogenous levels of total CD31 protein. It does not cross-react with other related proteins. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with recombinant human CD31 protein. Western Blotting
Western blot analysis of extracts from HUVEC cells using CD31 (PECAM-1) (89C2) Mouse mAb. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human smooth muscle using CD31 (PECAM-1) (89C2) Mouse mAb. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded HUVEC pellets using CD31 (PECAM-1) (89C2) Mouse mAb. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human clear cell carcinoma using CD31 (PECAM-1) (89C2) Mouse mAb. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human capillary hemangioma using CD31 (PECAM-1) (89C2) Mouse mAb. Flow Cytometry
Flow cytometric analysis of HeLa cells (red) and HUVEC (blue), using CD31 (PECAM-1) (89C2) Mouse mAb. IF-IC
Confocal immunofluorescent analysis of HUVEC (left) and HeLa cells (right) using CD31 (PECAM-1) (89C2) Mouse mAb (green). Actin filaments have been labeled with DY-554 phalloidin (red). Blue pseudocolor = DRAQ5™ (fluorescent DNA dye). |
| Background | CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells and endothelial cells, and modulates cell adhesion, endothelial cell migration and angiogenesis (1). CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical stress or oxidative stress), presumably by Src family members (2). The tyrosine phosphorylation mediates associations with a number of SH2 domain containing binding partners such as PI3-kinase, SHIP, PLCγ and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules (3). |
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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- 作者
- 内容
- 询问日期
文献和实验细胞粘附分子（N-CAM）之间的相互识别，血小板内皮细胞粘附分子-1（PECAM-1，CD31）的相互识别；②异嗜性相互作用（ heterophilic interaction）,如CD2与LFA-3，CD4与MHCⅡ类分子的单态部分（α2和β2），CD8与MHCⅠ类分子的单态部分（α3），poly IgR与多聚Ig,FcγRⅠ (CD64)、FcγRⅡ(CD32)、FcγRⅢ（CD16）与IgG Fc 段，FcγRⅠ与Ige Fc段，FcαR（CD89）与IgA Fc段，CD28与B7/BB1（CD
、IgFc段受体、细胞间粘附分子以及病毒受体等不同的结构域。IGSF识别的基本方式有以下几种。 1.IGSF和IGSF相互识别 IGSF分子相互识别中有嗜同种的相互作用和异嗜性相互作用两种形式。（1）嗜同种的相互作用（homophilic interaction)：如相同神经细胞粘附分子（NCAM）之间的相互识别，血小板内皮细胞粘附分子-1（PECAM-1，CD31）的相互识别。（2）异嗜性相互作用（heterophilic interaction)，如CD2与LFA
域。IGSF识别的基本方式有以下几种。 1.IGSF和IGSF相互识别 IGSF分子相互识别中有嗜同种的相互作用和异嗜性相互作用两种形式。（1）嗜同种的相互作用（homophilic interaction)：如相同神经细胞粘附分子（NCAM）之间的相互识别，血小板内皮细胞粘附分子-1（PECAM-1，CD31）的相互识别。（2）异嗜性相互作用（heterophilic interaction)，如CD2与LFA-3，CD4与MHC Ⅱ类分子的单态部分（α2和β2），CD8与MHCⅠ类分子的单态
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