重组绵羊IFN-τ北京厂家

特别提示：包括重组绵羊IFN-τ在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组绵羊IFN-τ
英文名称：Recombinant Ovine Interferon-tau
产品货号：GS4416
产品规格：2μg

分子量：Approximately 19.9kDa,a single non-glycosylated polypeptide chain containing 172 amino acids.
储存条件：冷冻（-20℃）

概述

IFN-τ is a new class of type I IFN that is secreted by the trophoblast and is the signal for maternal recognition of pregnancy in sheep.IFN-τ has potent immunosuppressive and antiviral activities similar to other type I IFN but is less cytotoxic than IFN-α/β.The current investigation concerns the effect of recombinant ovine IFN-tau(rOvIFN-τ)on the modulation of MHC class I and II expression on cloned mouse cerebrovascular endothelial(CVE)cells.IFN-tau induced tyrosine phosphorylation of Stat1 and up regulated the expression of MHC class I on CVE.One proposed action by which type I IFN reduce the relapse rate in MS is via interference with IFN-γ-induced MHC class II expression.IFN-τwas shown to down regulate IFN-γ-induced MHC class II expression on CVE and,hence,may be of potential therapeutic value in down regulating inflammation in the central nervous system(CNS).IFN-τdid not upregulate the expression of MHC class II on CVE.IFN-τalso inhibited the replication of Theilers virus in CVE.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Pichia Pastoris
生物活性	Fully biologically active when compared to IFN-alpha.The specific activity determined by a viral resistance assay is no less than 1.0×107 IU/mg.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rOvIFN-τ as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	CYLSRKLMLD ARENLKLLDR MNRLSPHSCL QDRKDFGLPQ EMVEGDQLQK DQAFPVLYEM LQQSFNLFYT EHSSAAWDTT LLEQLCTGLQ QQLDHLDTCR GQVMGEEDSE LGNMDPIVTV KKYFQGIYDY LQEKGYSDCA WEIVRVEMMR ALTVSTTLQK RLTKMGGDLN SP

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