重组马IFN-γ北京厂家

特别提示：包括重组马IFN-γ在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组马IFN-γ
英文名称：Recombinant Equine Interferon -gamma (r EqIFN -γ)
产品货号：GS4908
产品规格：20μg

分子量：Approximately 16.7kDa,a single non-glycosylated polypeptide chain containing 143 amino acids.
储存条件：冷冻（-20℃）

概述

Interferon- gamma(IFN-γ),also known as Type II interferon or immune interferon,is a cytokine produced primarily by T -lymphocytes and natural killer cells.The protein shares no significant homology with IFN-β or the various IFN- α family proteins.Mature IFN-γ exists as noncovalently-linked homodimers.IFN-γ was originally characterized based on its antiviral activities.The protein also exerts antiproliferative,immunoregulatory and proinflammatory activities and is thus important in host defense mechanis ms.IFN-γ induces the production of cytokines,upregulates the expression of class I and II MHC antigens,Fc receptor and leukocyte adhesion molecules.It modulates macrophage effector functions,influences isotype switching and potentiates the secretion of immunoglobulins by B cells.Additionally,IFN-γ augments TH1 cell expansion and may be required for TH1 cell differentiation.Equine IFN-γ shares 73%~82%amino acid sequence identity with bovine,canine,feline,and porcine IFN-γ and 42%~64%with cotton rat,human,murine,rat,and rhesus macaque IFN-γ.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze- dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by an anti - viral assay using human HeLa cells infected w ith encephalomyocarditis(EMC)virus is less than 10.0ng/ml,corresponding to a specific activity of>1.0×105 IU/mg.
成分	Lyophilized from a 0.2 μ m filtered concen trated solution in 2×PBS,pH 7.4,with 5%trehalose.
内毒素	Less than 0.1 EU/μ g of rEqIFN -γ as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	QAAFFKEIEN LKEYFNASNP DVGDGGPLFL DILKNWKEDS DKKIIQSQIV SFYFKLFENL KDNQVIQKSM DTIKEDLFVK FFNSSTSKLE DFQK LIQIPV NDLKVQRKAI SELIKVMNDL SPKANLRKRK RSQNPFRGRR ALQ

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