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- 详细信息
- 技术资料
- 细胞形态：
淋巴样
- 生长状态：
悬浮生长
- 物种来源：
小鼠
- 是否是肿瘤细胞：
0
- 细胞类型：
其他细胞类型
- 器官来源：
胸腺
- 品系：
DBA/2
- 库存：
大量
- 相关疾病：
淋巴瘤
- 运输方式：
冻存运输
- ATCC Number：
CRL-1722™
| Designations: | L5178-R (LY-R) | ||
| Depositors: | JZ Beer | ||
| Biosafety Level: | 1 | ||
| Shipped: | frozen | ||
| Medium & Serum: | See Propagation | ||
| Growth Properties: | suspension | ||
| Organism: | Mus musculus | ||
| Morphology: | lymphoblast |
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| Source: | Organ: thymus Strain: DBA/2 Disease: lymphoma Cell Type: chemically induced |
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| Permits/Forms: | In addition to the MTA mentioned above, other ATCC and/or regulatory permits may be required for the transfer of this ATCC material. Anyone purchasing ATCC material is ultimately responsible for obtaining the permits. Please click here for information regarding the specific requirements for shipment to your location. | ||
| Applications: | This cell line was derived from the L5178 thymic lymphoma induced by methylcholanthrene in a DBA/2 mouse. The cells are resistant to X-rays, but sensitive to ultraviolet radiation, heat and some potential anti neoplastic drugs (e. The X-ray sensitive L5178-S line (ATCC CRL-1723 ) was derived from this line. Tested and found negative for ectromelia virus. |
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| Tumorigenic: | Yes | ||
| Comments: | This cell line was derived from the L5178 thymic lymphoma induced by methylcholanthrene in a DBA/2 mouse. The cells are resistant to X-rays, but sensitive to ultraviolet radiation, heat and some potential anti neoplastic drugs (e.g., cis-PAD). After 6 months to 3 years in culture, the line converts to an X-ray sensitive state. The X-ray sensitive L5178-S line (ATCC CRL-1723 ) was derived from this line. Tested and found negative for ectromelia virus. |
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| Propagation: | ATCC complete growth medium: Fischer's medium with 0.1 g/L sodium pyruvate and 1.125 g/L sodium bicarbonate, 90%; horse serum, 10% |
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| Subculturing: | Medium Renewal: Twice per week Cultures can be maintained by addition or replacement of fresh medium. Start cultures at 4 X 10 exp4 cells/ml and maintain between 3 X 10 exp4 and 7 X 10 exp5 cells/ml. |
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| Preservation: | culture medium, 90%; DMSO, 10% | ||
| References: | 1164: Beer JZ, et al. X-ray and UV mutagenesis in two L5178Y cell strains differing in tumorigenicity, radiosensitivity, and DNA repair. Br. J. Cancer Suppl. 6: 107-111, 1984. PubMed: 6582899 1166: Beer JZ, et al. Loss of tumorigenicity with simultaneous changes in radiosensitivity and photosensitivity during in vitro growth of L5178Y murine lymphoma cells. Cancer Res. 43: 4736-4742, 1983. PubMed: 6883332 58059: Beer JZ, et al. Effects of low dose rate (0.003-0.025 Gy/h) chronic X-irradiation on radioresistant and radiosensitive L5178Y mouse lymphoma cells. Int. J. Radiat. Biol. 48: 609-619, 1985. PubMed: 3876312 |
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L5178-R (LY-R)
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