Ferrostatin-1,347174-05-4

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Ferrostatin-1

CAS No. : 347174-05-4

MCE 国际站：Ferrostatin-1

产品活性：Ferrostatin-1 (Fer-1) 是一种有效的、选择性的 ferroptosis 抑制剂，抑制 Erastin 诱导的 HT-1080 细胞铁死亡 (EC₅₀=60 nM)。Ferrostatin-1 是一种人工合成的抗氧化剂，通过还原机制来防止膜脂的损伤，从而抑制细胞死亡。Ferrostatin-1 具有抗真菌活性。

研究领域：Apoptosis  |  Anti-infection

作用靶点：Ferroptosis  |  Fungal

In Vitro: Ferrostatin-1 prevents erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 prevents glutamate-induced neurotoxicity in organotypic rat brain slices.
Ferrostatin-1 (2 μM; 24 h) prevents Glutamate (5 mM)-induced neurotoxicity in a rat organotypic hippocampal slice culture (OHSC).
Ferrostatin-1 inhibits lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability.
Ferrostatin-1 inhibits cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction.
Ferrostatin-1 (1 μM; 6 h) inhibits the oxidative destruction of unsaturated fatty acids in HT-1080 cells, thus increases the number of healthy medium spiny neurons (MSNs).

In Vivo: Ferrostatin-1 (5 mg/kg; ip; single dose, 30 min before glycerol injection) improves renal function in mice with rhabdomyolysis, whereas no beneficial effects were observed with the pan-caspase inhibitor zVAD or in RIPK3-deficient mice.
Ferrostatin-1 (0.8 mg/kg; tail vein injection) effectively alleviates LPS-induced induced acute lung injury (ALI).
Ferrostatin-1 (i.p.; 5 mg/kg; C57BL/6J mice) improves renal function in mice with rhabdomyolysis.

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