人参皂苷Rg1

使用本产品的案例（仅供参考）

In Vivo

Rat（healthy male SD rats of SPF class, weighing 200 ± 25 g；0.5 mL 12–5 g/mL Ginsenoside Rg1，每天灌胃，8周）

The rats were randomly divided into 3 groups (40/group): normal rats group (NC); DR rats (Model); g1-treated DR rats group (Rg1). The rats were acclimatized and housed for 1 week before the experiment, and they were fed and watered ad libitum. The rats in the diabetic group were fasted for 12 h before modeling and weighed before the experiment. In the diabetic group, freshly prepared STZ in bufer (55 mg/kg) was injected once into the left lower abdominal cavity, and the rats ate and drank normally after the injection. After the rats were injected with STZ for 48 h, the blood glucose and body weight were measured. Additionally, in the diabetic rat models, blood glucose >16.7 mmol/L, polyuria, and polyphagia were considered. The blood glucose and body weight of the rats were observed once every 2 weeks. In the Rg1 group, gavage was started on the day of modeling, and 0.5 mL (12–5 g/ml) of Rg1 solution (Solarbio, Beijing,China) was given by gavage every day, while the same dose of saline was given to the model and NC groups. The rats were sacrifced 8 weeks after modeling, and fresh retinal specimens were removed and preserved for the relevant assays.

来源文献：Xue L, Hu M, Li J, Li Y, Zhu Q, Zhou G, Zhang X, Zhou Y, Zhang J, Ding P. Ginsenoside Rg1 Inhibits High Glucose-Induced Proliferation, Migration, and Angiogenesis in Retinal Endothelial Cells by Regulating the lncRNA SNHG7/miR-2116-5p/SIRT3 Axis. J Oncol. 2022 Dec 3;2022:6184631. doi: 10.1155/2022/6184631. PMID: 36510610; PMCID: PMC9741534.

Mouse（C57 mice，injected intraperitoneally，20 mg kg⁻¹）

C57 mice in the neomycin-treated group were subcutaneously injected with neomycin at a dose of 200 mg kg⁻¹ daily from P7 to P13 C57 mice in the ginsenoside Rg1 group were injected subcutaneously with the same dose of neomycin everyday from P7 to P13 and then were immediately injected intraperitoneally with ginsenoside Rg1(Solarbio, IG0240) at a dose of 20 mg kg⁻¹.Ginseno- side Rg1 was dissolved in DMSO to prepare a storage solution according to the instructions and then prepared as a working solution with physiological saline. The normal control group was injected subcutaneously with the same volume of sterile saline or vehicle.

来源文献：Qi M, Gao Z, Qiu Y, Wang R, Tian K, Yue B, Zhang X, Zhang P, Wu Z, Zhu Q, Liu Z, Ma Z, Zhou X, Han Y, Chen J, Qiu J, Zha D. NOX2 Contributes to High-Frequency Outer Hair Cell Vulnerability in the Cochlea. Adv Sci (Weinh). 2025 Jun 26:e08830. doi: 10.1002/advs.202408830. Epub ahead of print. PMID: 40569247.

Xue L, et al. J Oncol. 2022 Dec 3;2022:6184631.

Xue L, et al. J Oncol. 2022 Dec 3;2022:6184631.