SJG-136 NSC 694501

SJG-136

SJG-136 (NSC 694501)是随机设计的PBD二聚体（pyrrolobenzodiazepine dimers），即将进入二期临床试验，用于治疗恶性疾病。NCI（National Cancer Institute）在60余种癌症细胞中测试发现，SJG-136显示细胞毒性强烈。

CAS: 232931-57-6

同义词: SJG 136；SP-2001；BN 2629；NSC 694501。Pyrrolo[2,1-c][1,4]benzodiazepine dimer；1,1'- [[(propane-1,3-diyl)dioxy]bis[(11aS)-7-methoxy-2-methylidene- 1,2,3,11a-tetrahydro-5H-pyr- rolo[2,1-c][1,4]benzodiazepin-5-one]]; (10Z,10'Z,11aS,11a'S)-8,8'-(propane-1,3-diylbis(oxy))bis(7-methoxy-2- methylene-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin- 5(11aH)-one)。

IUPAC/Chemical name:(11aS,11a'S)-8,8'-(propane-1,3-diylbis(oxy))bis(7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one)

分子式：C31H32N4O6

分子量：M.t. 556.61

货号	产品名称	化学结构式	分子式	纯度	价格(US $)
D1004	SJG-136		C31H32N4O6 M.t. 556.61	95%	Inquiry

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5.Hartley JA, Spanswick VJ, Brooks N, et al SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum anti-tumour activity. Part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity. Cancer Res, 2004; 64: 6693-9,

6 Gregson, S.J., et al., Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity. J Med Chem, 2001. 44(5): p. 737-48.

7. Hopton, S.R. and A.S. Thompson, Nuclear magnetic resonance solution structures of inter- and intrastrand adducts of DNA cross-linker SJG-136. Biochemistry, 2011. 50(21): p. 4720-32.

8. Alley, M. C., M. G. Hollingshead, et al. (2004). "SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations." Cancer Res 64(18): 6700-6706.