Binding Mode:Covalent adduction to N2-G in DNA minor groove; aromatic ring oriented to the 3' side of the
adduct, also in minor groove [Boyd, 1990].
Effect on DNA:Aromatic group of tomamycin is positioned to the 3' side of the covalent adduct in one NMR
solution study. Overall helical distortion is minimal [Boyd, 1990]. Depending on sequence, bends
DNA 8.25o to 14o [Kizu, 1993].