Tocris货号4635-10mg与50mg现货SC 79上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
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Tocris货号4635-10mg与50mg现货SC 79上

海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
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  • Tocris bioscience
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  • 2025年11月16日
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    上海睿安生物科技有限公司
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 库存：

      30⁺瓶

    • 英文名：

      SC 79

    • CAS号：

      305834-79-1

    • 保质期：

      1年

    • 供应商：

      上海睿安生物19121878899

    • 保存条件：

      -20°C

    • 规格：

      10mg/瓶

    Tocris货号4635-10mg与50mg现货SC 79上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商

    Description:Akt activator

    Chemical Name:2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester

    Biological Activity

    SC 79 is an activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.

    Technical Data

    M.Wt:364.78
    Formula:C17H17ClN2O5
    Solubility:Soluble to 100 mM in DMSO
    Storage:Store at -20°C
    CAS No:305834-79-1

    The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
    Tocris products are intended for laboratory research use only, unless stated otherwise.

     

    Background References

    1. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death.
      Jo et al.
      Proc.Natl.Acad.Sci.USA, 2012;109:10581

     

    Citations for SC 79

    The citations listed below are publications that use Tocris products. Selected citations for SC 79 include:

    11 Citations: Showing 1 - 10

    1.  Regulation of Stress-Activated Kinases in Response to Tacaribe Virus Infection and Its Implications for Viral Replication.
      Authors: Lucie Et al.
      Viruses  2022;14
    2.  FGF20-FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti.
      Authors: Yutao Et al.
      Dev Dyn  2021;250:134-144
    3.  Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways.
      Authors: Marc Et al.
      J Biol Chem  2020;295:16906-16919
    4.  Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways.
      Authors: Marc Et al.
      J Biol Chem  2020;295:16906-16919
    5.  Engineered antibody-functionalized porous silicon nanoparticles for therapeutic targeting of pro-survival pathway in endogenous neuroblasts after stroke.
      Authors: Andrii Et al.
      Biomaterials  2020;227:119556
    6.  GIV/Girdin promotes cell survival during endoplasmic reticulum stress.
      Authors: Peter Et al.
      Mol Cell Biochem  2019;453:79-88
    7.  Using low-risk factors to generate non-integrated human induced pluripotent stem cells from urine-derived cells.
      Authors: Wang Et al.
      Stem Cell Res Ther  2017;8:245
    8.  miR-382 targeting PTEN-Akt axis promotes liver regeneration.
      Authors: Bei Et al.
      Mol Syst Biol  2016;7:1584
    9.  SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination.
      Authors: Wilson Et al.
      Sci Rep  2016;6:17735
    10.  A small molecule activator of AKT does not reduce ischemic injury of the rat heart.
      Authors: Moreira Et al.
      J Transl Med  2015;13:76

     

     

    Tocris货号4635-10mg与50mg现货SC 79上Tocris货号4635-10mg与50mg现货SC 79上Tocris货号4635-10mg与50mg现货SC 79上Tocris货号4635-10mg与50mg现货SC 79上

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    该产品被引用文献

    Tocris货号4635-10mg与50mg现货SC 79上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商

    Description:Akt activator

    Chemical Name:2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester

    Biological Activity

    SC 79 is an activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.

    Technical Data

    M.Wt:364.78
    Formula:C17H17ClN2O5
    Solubility:Soluble to 100 mM in DMSO
    Storage:Store at -20°C
    CAS No:305834-79-1

    The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
    Tocris products are intended for laboratory research use only, unless stated otherwise.

     

    Background References

    1. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death.
      Jo et al.
      Proc.Natl.Acad.Sci.USA, 2012;109:10581

     

    Citations for SC 79

    The citations listed below are publications that use Tocris products. Selected citations for SC 79 include:

    11 Citations: Showing 1 - 10

    1.  Regulation of Stress-Activated Kinases in Response to Tacaribe Virus Infection and Its Implications for Viral Replication.
      Authors: Lucie Et al.
      Viruses  2022;14
    2.  FGF20-FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti.
      Authors: Yutao Et al.
      Dev Dyn  2021;250:134-144
    3.  Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways.
      Authors: Marc Et al.
      J Biol Chem  2020;295:16906-16919
    4.  Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways.
      Authors: Marc Et al.
      J Biol Chem  2020;295:16906-16919
    5.  Engineered antibody-functionalized porous silicon nanoparticles for therapeutic targeting of pro-survival pathway in endogenous neuroblasts after stroke.
      Authors: Andrii Et al.
      Biomaterials  2020;227:119556
    6.  GIV/Girdin promotes cell survival during endoplasmic reticulum stress.
      Authors: Peter Et al.
      Mol Cell Biochem  2019;453:79-88
    7.  Using low-risk factors to generate non-integrated human induced pluripotent stem cells from urine-derived cells.
      Authors: Wang Et al.
      Stem Cell Res Ther  2017;8:245
    8.  miR-382 targeting PTEN-Akt axis promotes liver regeneration.
      Authors: Bei Et al.
      Mol Syst Biol  2016;7:1584
    9.  SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination.
      Authors: Wilson Et al.
      Sci Rep  2016;6:17735
    10.  A small molecule activator of AKT does not reduce ischemic injury of the rat heart.
      Authors: Moreira Et al.
      J Transl Med  2015;13:76

     

     

    Tocris货号4635-10mg与50mg现货SC 79上Tocris货号4635-10mg与50mg现货SC 79上Tocris货号4635-10mg与50mg现货SC 79上Tocris货号4635-10mg与50mg现货SC 79上

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