Tocris货号0439-100mg现货8-Cyclopentyl-1,3-dipropylxanthine(DPCPX)上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
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Tocris货号0439-100mg现货8-Cyclopen

tyl-1,3-dipropylxanthine(DPCPX)上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 库存：

      30⁺瓶

    • 英文名：

      8-Cyclopentyl-1,3-dipropylxanthine(DPCPX)

    • CAS号：

      102146-07-6

    • 保质期：

      1年

    • 供应商：

      上海睿安生物19121878899

    • 保存条件：

      Room Temperature

    • 规格：

      100mg/瓶

    Tocris货号0439-100mg现货8-Cyclopentyl-1,3-dipropylxanthine(DPCPX)上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商

    Description:Selective A1 antagonist

    Chemical Name:8-Cyclopentyl-1,3-dipropylxanthine

    Purity:≥98%

     

    Biological Activity

    DPCPX is a potent and selective A1 adenosine receptor antagonist, both in vitro and in vivo. Ki values are 3.9, 130, 50 and 4000 nM for human A1, A2A, A2B and A3 receptors respectively.

    Technical Data

    M.Wt:304.39
    Formula:C16H24N4O2
    Solubility:Soluble to 5 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming
    Purity:≥98%
    Storage:Store at RT
    CAS No:102146-07-6

    The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
    Tocris products are intended for laboratory research use only, unless stated otherwise.

     

    Background References

    1. Adenosine is required for sustained inflammasome activation via the A(2)A receptor and the HIF-1alpha pathway.
      Ouyang X, Ghani A, Malik A, Wilder T, Colegio O, Flavell R, Cronstein B, Mehal W
      Nat Commun, 2013;4(0):2909.
    2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
      Fox JT, Sakamuru S, Huang R
      Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
    3. Activation of A1-adenosine receptors promotes leukocyte recruitment to the lung and attenuates acute lung injury in mice infected with influenza A/WSN/33 (H1N1) virus.
      Aeffner F, Woods P, Davis I
      J Virol, 2014;88(17):10214-27.
    4. Importance of GluA1 subunit-containing AMPA glutamate receptors for mor_phine state-dependency.
      Aitta-aho T, Moykkynen TP, Panhelainen AE, Vekovischeva OY, Backstrom P, Korpi ER
      PLoS ONE, 2012;7(5):e38325.
    5. Metabolic challenge to glia activates and adenosine-mediated safety mechanism that promotes neuronal survival by delaying the onset of spreading depression waves.
      Canals et al.
      J.Cereb.Blood Flow Metab., 2008;28:1835
    6. An experimental paradigm for investigating the role of endogenous adenosine/A1 receptor interactions in vivo.
      Kuan et al.
      J.Pharmacol.Exp.Ther., 1992;263:657
    7. Adenosine receptors and their ligands.
      Klot
      Naunyn Schmiedebergs Arch.Pharmacol., 2000;362:382
    8. Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations.
      Von der Leyen
      Naunyn Schmiedebergs Arch.Pharmacol., 1989;340:204

     

    Citations for DPCPX

    The citations listed below are publications that use Tocris products. Selected citations for DPCPX include:

    45 Citations: Showing 1 - 10

    1.  Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect.
      Authors: Liu Et al.
      Brain Res.  2018;1700:47
    2.  Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
      Authors: Angelantonio Et al.
      J Inflamm (Lond)  2015;9:409
    3.  Application of BRET to monitor ligand binding to GPCRs.
      Authors: Stoddart Et al.
      Nat Methods  2015;12:661
    4.  Anti-inflammatory effects of adenosine N1-oxide.
      Authors: Kohno Et al.
      Am J Physiol Lung Cell Mol Physiol  2015;12:2
    5.  Creatine, similarly to KA, affords antidepressant-like effects in the tail suspension test via adenosine A1� and A2A receptor activation.
      Authors: Cunha Et al.
      J Clin Invest  2015;11:215
    6.  Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
      Authors: Dobson Et al.
      J Neurosci  2015;10:e0125974
    7.  Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.
      Authors: Carlsen and Perrier
      Front Neural Circuits  2014;8:60
    8.  Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light.
      Authors: Ruby Et al.
      Korean J Anesthesiol  2014;39:2432
    9.  Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina.
      Authors: Li Et al.
      Vis Neurosci  2014;31:237
    10.  Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.
      Authors: Diógenes Et al.
      Cereb Cortex  2014;24:67

    Tocris货号0439-100mg现货8-CyclopenTocris货号0439-100mg现货8-CyclopenTocris货号0439-100mg现货8-CyclopenTocris货号0439-100mg现货8-Cyclopen

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    图标文献和实验
    该产品被引用文献

    Tocris货号0439-100mg现货8-Cyclopentyl-1,3-dipropylxanthine(DPCPX)上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商

    Description:Selective A1 antagonist

    Chemical Name:8-Cyclopentyl-1,3-dipropylxanthine

    Purity:≥98%

     

    Biological Activity

    DPCPX is a potent and selective A1 adenosine receptor antagonist, both in vitro and in vivo. Ki values are 3.9, 130, 50 and 4000 nM for human A1, A2A, A2B and A3 receptors respectively.

    Technical Data

    M.Wt:304.39
    Formula:C16H24N4O2
    Solubility:Soluble to 5 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming
    Purity:≥98%
    Storage:Store at RT
    CAS No:102146-07-6

    The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
    Tocris products are intended for laboratory research use only, unless stated otherwise.

     

    Background References

    1. Adenosine is required for sustained inflammasome activation via the A(2)A receptor and the HIF-1alpha pathway.
      Ouyang X, Ghani A, Malik A, Wilder T, Colegio O, Flavell R, Cronstein B, Mehal W
      Nat Commun, 2013;4(0):2909.
    2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
      Fox JT, Sakamuru S, Huang R
      Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
    3. Activation of A1-adenosine receptors promotes leukocyte recruitment to the lung and attenuates acute lung injury in mice infected with influenza A/WSN/33 (H1N1) virus.
      Aeffner F, Woods P, Davis I
      J Virol, 2014;88(17):10214-27.
    4. Importance of GluA1 subunit-containing AMPA glutamate receptors for mor_phine state-dependency.
      Aitta-aho T, Moykkynen TP, Panhelainen AE, Vekovischeva OY, Backstrom P, Korpi ER
      PLoS ONE, 2012;7(5):e38325.
    5. Metabolic challenge to glia activates and adenosine-mediated safety mechanism that promotes neuronal survival by delaying the onset of spreading depression waves.
      Canals et al.
      J.Cereb.Blood Flow Metab., 2008;28:1835
    6. An experimental paradigm for investigating the role of endogenous adenosine/A1 receptor interactions in vivo.
      Kuan et al.
      J.Pharmacol.Exp.Ther., 1992;263:657
    7. Adenosine receptors and their ligands.
      Klot
      Naunyn Schmiedebergs Arch.Pharmacol., 2000;362:382
    8. Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations.
      Von der Leyen
      Naunyn Schmiedebergs Arch.Pharmacol., 1989;340:204

     

    Citations for DPCPX

    The citations listed below are publications that use Tocris products. Selected citations for DPCPX include:

    45 Citations: Showing 1 - 10

    1.  Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect.
      Authors: Liu Et al.
      Brain Res.  2018;1700:47
    2.  Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
      Authors: Angelantonio Et al.
      J Inflamm (Lond)  2015;9:409
    3.  Application of BRET to monitor ligand binding to GPCRs.
      Authors: Stoddart Et al.
      Nat Methods  2015;12:661
    4.  Anti-inflammatory effects of adenosine N1-oxide.
      Authors: Kohno Et al.
      Am J Physiol Lung Cell Mol Physiol  2015;12:2
    5.  Creatine, similarly to KA, affords antidepressant-like effects in the tail suspension test via adenosine A1� and A2A receptor activation.
      Authors: Cunha Et al.
      J Clin Invest  2015;11:215
    6.  Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
      Authors: Dobson Et al.
      J Neurosci  2015;10:e0125974
    7.  Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.
      Authors: Carlsen and Perrier
      Front Neural Circuits  2014;8:60
    8.  Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light.
      Authors: Ruby Et al.
      Korean J Anesthesiol  2014;39:2432
    9.  Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina.
      Authors: Li Et al.
      Vis Neurosci  2014;31:237
    10.  Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.
      Authors: Diógenes Et al.
      Cereb Cortex  2014;24:67

    Tocris货号0439-100mg现货8-CyclopenTocris货号0439-100mg现货8-CyclopenTocris货号0439-100mg现货8-CyclopenTocris货号0439-100mg现货8-Cyclopen

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