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Tocris货号0495-25mg现货(±)-U-50488

hydrochloride上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商

价格￥2646.01

品牌Tocris bioscience
货号0495-25mg
产地made in USA
更新日期2026年02月26日

上海睿安生物科技有限公司

12 年金牌会员

Biological Activity

(±)-U-50488 hydrochloride is a selective κ-opioid agonist.At higher concentrations blocks Na⁺ channels.

(-)-enantiomer and (+)-enantiomer also available.

Technical Data

M.Wt:405.79

Formula:C₁₉H₂₆Cl₂N₂O.HCl

Solubility:Soluble to 25 mM in water

Purity:≥99%

Storage:Store at RT

CAS No:67197-96-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only,unless stated otherwise.

Additional Information

Other Product-Specific Information:

(-)-enantiomer Available
(+)-enantiomer Available

Background References

Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells.
Kharmate G, Rajput P, Lin Y, Kumar U
Cancer Cell Int, 2013;13(1):93.
Development of functionally selective, small molecule agonists at kappa opioid receptors.
Zhou L, Lovell K, Frankowski K, Slauson S, Phillips A, Streicher J, Stahl E, Schmid C, Hodder P, Madoux F, Cameron M, Prisinzano T, Aube J, Bohn L
J Biol Chem, 2013;288(51):36703-16.
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
Cardiovascular actions of the κ-agonist, U-50-488H, in the absence and presence of opioid receptor blockade.
Pugsley et al.
Br.J.Pharmacol., 1992;105:521
U-50,488 blocks the development of mor. tolerance and dependence at a very low dose in guinea pigs.
Pao-Luh Tao et al.
Eur.J.Pharmacol., 1994;256:281
Activation of kappa opioid receptors by U-50488H and mor. enhances the release of substance P from rat trigeminal nucleus slices.
Suarez-Roca and Maixner
J.Pharmacol.Exp.Ther., 1993;264:648
Blockade of the development of mor. tolerance by U-50,488, an AVP antagonist or MK 801 in the rat hippocampal slice.
Su et al.
Br.J.Pharmacol., 1998;123:625

Citations for (±)-U-50488 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for (±)-U-50488 hydrochloride include:

9 Citations: Showing 1 - 9

Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis
Authors: Pirino Et al.
Neuropharmacology 2020;181:108341
Kappa opioid receptor agonists improve postoperative cognitive dysfunction in rats via the JAK2/STAT3 signaling pathway.
Authors: Li Et al.
Int J Mol Med 2019;
sMu opioid receptor agonist DAMGO produces place conditioning, abstinence-induced withdrawal, and nal_trexone-dependent locomotor activation in planarians.
Authors: Dziedowiec Et al.
Neuroscience 2018;386:214
In vivo brain GPCR signaling elucidated by phosphoproteomics.
Authors: Liu
Science 2018;360(6395):eaao4927
Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapsesfollowing acute stress
Authors: Polter
Elife 2017;6:e23785
Development of functionally selective, small molecule agonists at kappa opioid receptors.
Authors: Zhou Et al.
J Biol Chem 2013;288:36703
Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells.
Authors: Kharmate Et al.
Cancer Cell Int 2013;13:93
GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats.
Authors: Grachev Et al.
Pain 2012;7:e44344
Medial dorsal hypothalamus mediates the inhibition of reward seeking after extinction.
Authors: Marchant Et al.
J Neurosci 2010;30:14102

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

产品细节图片1 产品细节图片2 产品细节图片3 产品细节图片4

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文献和实验

该产品被引用文献

Tocris货号0495-25mg现货(±)-U-50488 hydrochloride上海睿安生物19121878899安迪Bio-Techne(R&D Systems-Tocris)官方正式授权代理商

Description:Selective κ agonist

Chemical Name:trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride

Purity:≥99%

Biological Activity

(±)-U-50488 hydrochloride is a selective κ-opioid agonist.At higher concentrations blocks Na⁺ channels.

(-)-enantiomer and (+)-enantiomer also available.

Technical Data

M.Wt:405.79

Formula:C₁₉H₂₆Cl₂N₂O.HCl

Solubility:Soluble to 25 mM in water

Purity:≥99%

Storage:Store at RT

CAS No:67197-96-0

Additional Information

Other Product-Specific Information:

(-)-enantiomer Available
(+)-enantiomer Available

Background References

Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells.
Kharmate G, Rajput P, Lin Y, Kumar U
Cancer Cell Int, 2013;13(1):93.
Development of functionally selective, small molecule agonists at kappa opioid receptors.
Zhou L, Lovell K, Frankowski K, Slauson S, Phillips A, Streicher J, Stahl E, Schmid C, Hodder P, Madoux F, Cameron M, Prisinzano T, Aube J, Bohn L
J Biol Chem, 2013;288(51):36703-16.
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
Cardiovascular actions of the κ-agonist, U-50-488H, in the absence and presence of opioid receptor blockade.
Pugsley et al.
Br.J.Pharmacol., 1992;105:521
U-50,488 blocks the development of mor. tolerance and dependence at a very low dose in guinea pigs.
Pao-Luh Tao et al.
Eur.J.Pharmacol., 1994;256:281
Activation of kappa opioid receptors by U-50488H and mor. enhances the release of substance P from rat trigeminal nucleus slices.
Suarez-Roca and Maixner
J.Pharmacol.Exp.Ther., 1993;264:648
Blockade of the development of mor. tolerance by U-50,488, an AVP antagonist or MK 801 in the rat hippocampal slice.
Su et al.
Br.J.Pharmacol., 1998;123:625

Citations for (±)-U-50488 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for (±)-U-50488 hydrochloride include:

9 Citations: Showing 1 - 9

Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis
Authors: Pirino Et al.
Neuropharmacology 2020;181:108341
Kappa opioid receptor agonists improve postoperative cognitive dysfunction in rats via the JAK2/STAT3 signaling pathway.
Authors: Li Et al.
Int J Mol Med 2019;
sMu opioid receptor agonist DAMGO produces place conditioning, abstinence-induced withdrawal, and nal_trexone-dependent locomotor activation in planarians.
Authors: Dziedowiec Et al.
Neuroscience 2018;386:214
In vivo brain GPCR signaling elucidated by phosphoproteomics.
Authors: Liu
Science 2018;360(6395):eaao4927
Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapsesfollowing acute stress
Authors: Polter
Elife 2017;6:e23785
Development of functionally selective, small molecule agonists at kappa opioid receptors.
Authors: Zhou Et al.
J Biol Chem 2013;288:36703
Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells.
Authors: Kharmate Et al.
Cancer Cell Int 2013;13:93
GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats.
Authors: Grachev Et al.
Pain 2012;7:e44344
Medial dorsal hypothalamus mediates the inhibition of reward seeking after extinction.
Authors: Marchant Et al.
J Neurosci 2010;30:14102

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

引用文献图片1 引用文献图片2 引用文献图片3 引用文献图片4

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Biological Activity

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Citations for (±)-U-50488 hydrochloride

Biological Activity

Technical Data

Additional Information

Background References

Citations for (±)-U-50488 hydrochloride

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Biological Activity

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Citations for (±)-U-50488 hydrochloride

Biological Activity

Technical Data

Additional Information

Background References

Citations for (±)-U-50488 hydrochloride

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