西曲瑞克，Cetrorelix

产品描述

Cetrorelix Acetate is gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM.

靶点活性

GnRH,1.21 nM

体外活性

GnRH-I antagonist Cetrorelix inhibited growth of ES-2 cell line only at 1000 ng/ml.The incubation of ES-2 ovarian cancer cells in vitro with an GnRH-I antibody inhibited cell proliferation in a time and concentration-dependent manner. GnRH-I may function as an autocrine growth factor in this ovarian cancer cell line [1].

体内活性

Cetrorelix inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp6]GnRH (IC50 = 1.2 nM). In vivo, cetrorelix (60 μg per day) reduces tumor volume to 35% of control and decreases serum luteinizing hormone levels by 50% in a human epithelial ovarian cancer mouse xenograft model[2].

分子量

1491.11

分子式

C70H92ClN17O14.C2H4O2

CAS

145672-81-7

溶解度

DMSO: 50 mg/mL (33.53 mM)

（ < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.