- ￥3520
- novoprotein
- CK63
- CN
- 2025年07月10日
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- 详细信息
- 询价记录
- 技术资料
- 供应商：
上海研卉生物科技有限公司
- 库存：
大量
- 英文名：
Recombinant Human TRANCE/RANK L/TNFSF11/CD254
- 规格：
50ug
Recombinant Human TRANCE/RANK L/TNFSF11/CD254
产品说明(Description)
Recombinant Human Receptor Activator of NF-kappa-B ligand is produced by our E.coli expression system and the target gene encoding Ile140-Asp317 is expressed.
Accession #: O14788
Known as: CD254; ODF; OPGL; RANKL; TNFSF11; CD254; Osteoclast differentiation factor; Receptor activator of nuclear factor kappa-B ligand; tumor necrosis factor ligand superfamily member 11
制剂（Formulation）
Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0.
质量控制（Quality Control）
Purity: Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin: Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
Bioactivity: Immobilized ZRKLA (Cat#CK63) at 2μg/ml (100 μl/well) can bind Human OPG-His (Cat#C325)
The ED50 of ZRKLA (Cat#CK63) is 0.15 ug/ml .
复溶（Reconstitution）
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in distilled water
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
背景（Background）
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.
电泳(SDS-PAGE)
参考文献（References）
Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-κB Ligand (RANKL)—Receptor Activator of Nuclear Factor-κB (RANK) Protein–Protein Interaction by Structure-Based Virtual Screening and Hit Optimization[J]. Min Jiang. et al. Journal of Medicinal Chemistry. 2019.
FOR RESEARCH USE ONLY
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