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- 17594
- USA
- 2025年07月16日
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
研卉生物
- 英文名：
Angiotensin Fragment 1-7 (acetate)
- 规格：
1mg
Item № 17594
Purity ≥95%
Description
In the renin-angiotensin system, angiotensin I is cleaved by angiotensin-converting enzyme (ACE) to form angiotensin II, which has effects on blood pressure, as well as fluid and electrolyte homeostasis. Angiotensin fragment 1-7 is an angiotensin metabolite that functions as a type 1 angiotensin II receptor agonist whereupon it can control hydroelectrolyte balance and demonstrates vasodilatory and anti-inflammatory actions in opposition to various adverse effects of angiotensin II (Item No. 17150).1 This peptide can be generated by the action of ACE2, a homolog of ACE, on angiotensin II or by the action of neprilysin on angiotensin I.2 It has been studied in the context of ameliorating the symptoms of metabolic syndrome.3,4
| Formal Name | 5-L-isoleucine-1-7-angiotensin II |
| Molecular Formula | C41H62N12O11 • XC2H4O2 |
| Formula Weight | 899.0 |
| Purity | ≥95% |
| Formulation | A crystalline solid |
| SMILES | O=C([C@H](CC1=CNC=N1)NC([C@@]([H])(NC([C@H](CC2=CC=C(C=C2)O)NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)CCCNC(N)=N)=O)C(C)C)=O)=O)[C@H](CC)C)=O)N3CCC[C@H]3C(O)=O.CC(O)=O |
| InChI Code | 1S/C41H62N12O11.C2H4O2/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56;1-2(3)4/h10-13,19-22,26-30,3 |
| InChI Key | VJHCETPHKAQOHY-LBGFTJIYSA-N |
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文献和实验James Hardwick angiotensin assay protocol
2 mMolar [Val5]-angiotensin II 3. Remove 5 microliter aliquots of the reaction mixture after 1, 3, and 5 minutes of reaction time. The incorporation of ATP is linear during this period. The 5 microliter aliquots
Radiolabeling of Angiotensin Peptides
The use of radioiodinated angiotensins has contributed greatly to our knowledge of the renin-angiotensin system (RAS). This chapter provides brief descriptions of the application of radioiodinated angiotensins and other radioiodinated
Quantification of Angiotensin Peptides
There is an endogenous renin-angiotensin system in the kidney, and angiotensin (Ang) II generated within the kidney may play an important role in the regulation of renal hemodynamics and sodium excretion (1 –6 ). Assessment
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