- ¥780 - 2200
- LMAI Bio
- LM-8524R
- 进口/国产
- 2025年12月26日
- WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-8524R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Calcium Sensing Receptor
- 抗体名：
钙敏感受体1抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 免疫原：
KLH conjugated synthetic peptide derived from human Calcium Sensing Receptor/CaSR:121-220/1078 <Extracellular>
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul 200ul
| 英文名称 | Calcium Sensing Receptor |
| 中文名称 | 钙敏感受体1抗体 |
| 别 名 | Ca sensing receptor; Ca2+ sensing receptor 1; Ca2+ sensing receptor; CAR; CaSR; CASR_HUMAN; EIG8; Extracellular calcium sensing receptor; Extracellular calcium sensing receptor [Precursor]; Extracellular calcium-sensing receptor [Precursor]; Extracellular calcium-sensing receptor; FHH; FIH; GPRC2A; HHC; HHC1; Hypocalciuric hypercalcemia 1; Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism; MGC138441; NSHPT; Parathyroid Ca(2+) sensing receptor 1; Parathyroid Cell calcium sensing receptor; Parathyroid Cell calcium-sensing receptor; PCAR 1; PCAR1. |
 |
Specific References (1) | bs-8524R has been referenced in 1 publications. [IF=2.91] Huang, Bo, et al. "Chitosan oligosaccharide reduces intestinal inflammation that involves CaSR activation in LPS challenged-piglets." Journal of Agricultural and Food Chemistry (2016). WB ; Pig. PubMed:26654156 |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 神经生物学 信号转导 生长因子和激素 细胞骨架 细胞外基质 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 118kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Calcium Sensing Receptor/CaSR:121-220/1078 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Extracellular calcium-sensing receptor (CaSR), also designated parathyroid cell calcium-sensing receptor, is an integral membrane protein that belongs to the G protein-coupled receptor 3 family. CaSR is involved in maintaining a stable calcium concentration by acting as an sensor of the extracellular calcium levels for the parathyroid and kidney. Its activity is mediated by a G protein which activates a phosphatidylinositol-calcium second messenger Function: Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. Subunit: Interacts with VCP and RNF19A. Interacts with ARRB1 (By similarity). Subcellular Location: Cell membrane. Tissue Specificity: Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta. Post-translational modifications: N-glycosylated. Ubiquitinated by RNF19A; which induces proteasomal degradation. DISEASE: Defects in CASR are the cause of familial hypocalciuric hypercalcemia type 1 (FHH) [MIM:145980]. FHH is characterized by altered calcium homeostasis. Affected individuals exhibit mild or modest hypercalcemia, relative hypocalciuria, and inappropriately normal PTH levels. Defects in CASR are the cause of neonatal severe primary hyperparathyroidism (NSHPT) [MIM:239200]. NSHPT is a rare autosomal recessive life-threatening disorder characterized by very high serum calcium concentrations, skeletal demineralization, and parathyroid hyperplasia. In some instances NSHPT has been demonstrated to be the homozygous form of FHH. Defects in CASR are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. An autosomal recessive form of FIH also exists. Defects in CASR are the cause of epilepsy, idiopathic generalized type 8 (EIG8) [MIM:612899]. A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Seizure types are variable, but include myoclonic seizures, absence seizures, febrile seizures, complex partial seizures, and generalized tonic-clonic seizures. Note=Homozygous defects in CASR can be a cause of primary hyperparathyroidism in adulthood. Patients suffer from osteoporosis and renal calculi, have marked hypercalcemia and increased serum PTH concentrations. Similarity: Belongs to the G-protein coupled receptor 3 family. SWISS: P41180 Gene ID: 846 Database links: Entrez Gene: 281038 Cow Entrez Gene: 846 Human Entrez Gene: 12374 Mouse Entrez Gene: 24247 Rat Omim: 601199 Human SwissProt: P35384 Cow SwissProt: P41180 Human SwissProt: Q9QY96 Mouse SwissProt: P48442 Rat Unigene: 435615 Human Unigene: 103619 Mouse Unigene: 10019 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验升高，分别作用于骨、肾脏以及小肠等器官促进钙释放与吸收，从而上调血钙浓度；而当血钙浓度升高时，PTH 分泌降低，从而促使血钙回落至正常水平。 这些生理过程主要是由表达在甲状旁腺主细胞上的钙敏感受体（Calcium sensing receptors, CaSR）感受血钙浓度来实现对 PTH 的分泌调控的。然而在甲状旁腺亢进等病理条件下，甲旁腺主细胞增生并且无法精确感受血钙浓度变化，进而无法反馈调节 PTH 的高水平分泌。 「PTH 的异常增高导致病人出现高钙血症、情绪异常和骨丢失等系列症状
. Methods are described to aid verification and quantification of the mitochondrial calcium concentration using single or two photon confocal microscopy and combining the imaging with another cytosolic calcium sensing dye. The method of linear unmixing
成像技术（Imaging）一、钙离子成像技术（Calcium imaging）钙离子成像技术（Calcium imaging）是指利用钙离子指示剂监测组织内钙离子浓度的方法。在神经系统研究中，我们常用钙离子成像技术监测神经元内钙离子的变化，提示神经元活动。有了钙成像技术，原本悄无声息的电生理活动就变成了一幅形象地、斑斓闪烁的壮观影像，研究人员可以同时大量追踪神经元活动，研究其关系，因而被全世界神经科学家们追捧。1）钙离子成像技术原理在生物体内，钙离子是细胞信号产生的基础，在很多功能方面有重要
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